{"id":"W2169908590","doi":"10.1128/iai.69.11.6942-6950.2001","title":"Dual Role of Lipopolysaccharide (LPS)-Binding Protein in Neutralization of LPS and Enhancement of LPS-Induced Activation of Mononuclear Cells","year":2001,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Lipopolysaccharide; Lipopolysaccharide binding protein; Tumor necrosis factor alpha; Stimulation; Peripheral blood mononuclear cell; Acute-phase protein; Membrane; Lipid A; CD14; Biology; Bacterial outer membrane; Chemistry; Cell biology; Inflammation; Biochemistry; Immunology; In vitro; Receptor; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005027978,0.000618875,0.0004839755,0.0002420812,0.0001525238,0.0004025591,0.0002033267,0.0004714992,0.0009659004],"category_scores_gemma":[0.0003489018,0.0001624872,0.0002527107,0.0001086286,0.0004487624,0.0003085651,0.0004627242,0.0005682671,0.0004822419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000192647,"about_ca_system_score_gemma":0.0002015019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008798864,"about_ca_topic_score_gemma":0.0001136286,"domain_scores_codex":[0.9994962,0.0002155445,0.00003477474,0.00004202483,0.0001011232,0.0001102034],"domain_scores_gemma":[0.9996942,0.00007510555,0.00005246529,0.00003426167,0.0000539773,0.00008997953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003289339,0.00003735641,0.00008753524,0.00005453073,0.000002722231,0.00004340679,0.000009522711,0.00002239749,0.9981541,0.00009842763,0.0000106206,0.001150455],"study_design_scores_gemma":[0.00005109422,0.0007354249,0.003247698,0.00001296662,0.0000195947,0.0004075558,0.0000139616,0.0005111676,0.9929408,0.0001009441,0.001953302,0.000005406281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822357,0.009382626,0.005819217,0.0002018378,0.00007278805,0.00007463971,0.00009456756,0.0001080377,0.002010438],"genre_scores_gemma":[0.9922293,0.001528347,0.004522595,0.0001107872,0.00005028981,0.00006512474,0.000148154,0.00001881505,0.001326605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009659004,"threshold_uncertainty_score":0.003231227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171956226439355,"score_gpt":0.2327624647379249,"score_spread":0.2210429024735313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}