{"id":"W2169918679","doi":"10.1186/gb-2008-9-7-r115","title":"Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy","year":2008,"lang":"en","type":"article","venue":"Genome biology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Wilfrid Laurier University; Université Laval","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research","keywords":"Biology; Gene; Genetics; Aneuploidy; Human genetics; Gene expression; Gene dosage; Gene duplication; Chromosome; Molecular biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003772986,0.0001832639,0.0004984388,0.0002870819,0.0001405765,0.00000498536,0.00009864256,0.0001500061,0.00003649191],"category_scores_gemma":[0.0001672262,0.0001479095,0.00003680518,0.000363729,0.000306349,0.00007260557,0.00006560251,0.0001568903,0.000006656293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200066,"about_ca_system_score_gemma":0.0001008371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000186581,"about_ca_topic_score_gemma":0.00009287064,"domain_scores_codex":[0.9983076,0.0001749798,0.0004572674,0.0004782931,0.0002398368,0.0003420422],"domain_scores_gemma":[0.9988931,0.00008355824,0.000233412,0.0003482811,0.0003444169,0.00009724923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000325582,0.0001366362,0.1220538,0.0000307793,0.0000636386,0.00003261681,0.0009189576,0.00001671473,0.8762037,0.00001599385,0.00007909909,0.0001224929],"study_design_scores_gemma":[0.001536236,0.0004728014,0.8525299,0.00003776833,0.0000206448,0.00006801602,0.00006671271,0.00008301825,0.1446986,0.00007474332,0.0002768315,0.000134757],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962777,0.002012295,0.0004081641,0.0005147135,0.00002526752,0.0005677458,0.00006474654,0.00003611207,0.00009319083],"genre_scores_gemma":[0.9949743,0.001774967,0.002412128,0.00008976916,0.00007595328,0.00006200889,0.0003893861,0.00002604633,0.0001954513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7315052,"threshold_uncertainty_score":0.6031573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03195023407286249,"score_gpt":0.2721784680281125,"score_spread":0.24022823395525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}