{"id":"W2169929668","doi":"10.1039/b304252a","title":"Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin","year":2003,"lang":"en","type":"article","venue":"Chemical Communications","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lovastatin; Polyketide; Polyketide synthase; Chemistry; ATP synthase; Aspergillus nidulans; Biochemistry; Function (biology); Enzyme; Stereochemistry; Gene; Biology; Biosynthesis; Genetics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007671116,0.0002734202,0.0001700671,0.0001813935,0.0001596085,0.0002386359,0.00009876234,0.0001766299,0.0004765997],"category_scores_gemma":[0.0001388062,0.0000879685,0.0001265647,0.0001277404,0.0001591852,0.0001589134,0.0001866999,0.0002198768,0.0001994378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003725585,"about_ca_system_score_gemma":0.0003771272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057445,"about_ca_topic_score_gemma":0.002456921,"domain_scores_codex":[0.9999341,0.00001223514,0.00000719181,0.00001398821,0.00001734404,0.00001519885],"domain_scores_gemma":[0.9999317,0.000008108932,0.00001848003,0.000006538387,0.000006527333,0.00002865803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000243635,0.00001392624,0.0004388355,0.00003447941,0.000004855678,0.0002196553,0.00001355346,0.0001521683,0.995698,0.0002262228,0.0000507632,0.002903834],"study_design_scores_gemma":[0.00002374727,0.00031236,0.002337448,0.000005961281,0.00001423275,0.0006305382,0.00002161822,0.0003850765,0.9904819,0.0001004403,0.005678179,0.000008499558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879909,0.003288098,0.0043987,0.0001708975,0.00008084311,0.00005800874,0.0004879888,0.00008834957,0.003436152],"genre_scores_gemma":[0.9925829,0.001355798,0.003254457,0.00005271597,0.0000106299,0.00001204953,0.0005584234,0.00001025118,0.002162776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057445,"threshold_uncertainty_score":0.00270313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03574352602238479,"score_gpt":0.3026290854709583,"score_spread":0.2668855594485736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}