{"id":"W2169949084","doi":"10.1128/jvi.76.22.11688-11703.2002","title":"Age-Dependent Resistance to Lethal Alphavirus Encephalitis in Mice: Analysis of Gene Expression in the Central Nervous System and Identification of a Novel Interferon-Inducible Protective Gene, Mouse<i>ISG12</i>","year":2002,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Biology; Sindbis virus; Alphavirus infection; Alphavirus; Virology; ISG15; Interferon; Gene expression; Immunology; Virus; Encephalitis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034885,0.0005508334,0.0002718196,0.0007780656,0.0001928453,0.0003211746,0.0002304041,0.0004559055,0.0009529731],"category_scores_gemma":[0.0001241247,0.0002761318,0.0005114587,0.0003204504,0.0003143109,0.0003210029,0.0001666591,0.0006861116,0.0003385912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003408078,"about_ca_system_score_gemma":0.0001577557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005365686,"about_ca_topic_score_gemma":0.0008835508,"domain_scores_codex":[0.9997516,0.00002520815,0.00002867698,0.00007721929,0.00004911522,0.00006811415],"domain_scores_gemma":[0.9997635,0.00002261055,0.0001098609,0.00002011686,0.00002419621,0.00005966023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007975393,0.00001710015,0.0002283902,0.000008840891,0.00000231516,0.00001486555,0.00001003502,0.00001160561,0.9993411,0.00001642884,0.000006605047,0.0002630596],"study_design_scores_gemma":[0.00002874167,0.0008982393,0.04081681,0.00001080377,0.00003755039,0.0004577635,0.00005710863,0.0005643689,0.9558627,0.00005850146,0.001197685,0.000009746923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963325,0.0006871408,0.001519382,0.00005121524,0.00001271603,0.00003619008,0.0008123135,0.00004732679,0.000501194],"genre_scores_gemma":[0.9829437,0.00164498,0.004859637,0.0001309494,0.00002307801,0.0002420368,0.003342167,0.00008067464,0.006732848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009529731,"threshold_uncertainty_score":0.003187954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025910398502223,"score_gpt":0.2566053719865372,"score_spread":0.2363462680015149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}