{"id":"W2169951429","doi":"10.1371/journal.pgen.1000916","title":"Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups","year":2010,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":327,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ministry of Cultural Affairs; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; European Commission; Münchner Zentrum für Gesundheitswissenschaften; Heinz Nixdorf Stiftung; Bundesministerium für Bildung und Forschung; Ministry of Environment; Genome Canada","keywords":"Genome-wide association study; Biology; Single-nucleotide polymorphism; Genetics; Locus (genetics); Population; Population stratification; Genetic association; Linkage disequilibrium; Imputation (statistics); Genotyping; Genotype; Gene; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001223267,0.0003687681,0.001959632,0.0004945941,0.00007459539,0.00002307648,0.0002106537,0.0006031098,0.000004074888],"category_scores_gemma":[0.001750858,0.0003634472,0.0004258203,0.0004701571,0.00004330467,0.000004489702,0.000165675,0.0001982168,7.011469e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085973,"about_ca_system_score_gemma":0.00020329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007982929,"about_ca_topic_score_gemma":0.005568219,"domain_scores_codex":[0.9969782,0.0003821499,0.001364365,0.0007011355,0.0001834326,0.0003906643],"domain_scores_gemma":[0.9973643,0.0005810963,0.001185027,0.0004837474,0.0003105609,0.00007525025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003285444,0.0007227614,0.974153,0.00212432,0.007194208,0.000001215731,0.001255573,0.0002295167,0.0009950172,0.000008315228,0.0009342242,0.01234898],"study_design_scores_gemma":[0.002654229,0.0007665752,0.9491227,0.0003774343,0.01304851,0.000001012486,0.0001965447,0.002067797,0.0001892365,0.001444362,0.02918246,0.0009491305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5661788,0.4311394,0.0004982864,0.00002522082,0.00008581967,0.001889087,0.0001753235,0.000003993142,0.000004089007],"genre_scores_gemma":[0.1705078,0.8230231,0.003086204,0.00003912602,0.0002697839,0.0006146043,0.001983926,0.00005974315,0.0004157465],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.395671,"threshold_uncertainty_score":0.9998817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07085916339579838,"score_gpt":0.345489019429992,"score_spread":0.2746298560341936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}