{"id":"W2169965735","doi":"10.1101/gad.1192704","title":"Collaboration of Brca1 and Chk2 in tumorigenesis","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National University of Singapore; Amgen","keywords":"Biology; DNA damage; Checkpoint Kinase 2; Carcinogenesis; Context (archaeology); Cell biology; Phosphorylation; Cancer research; Signal transduction; Suppressor; DNA; Cancer; Genetics; Protein-Serine-Threonine Kinases; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200647,0.00007960483,0.00008846061,0.00004358698,0.0000228132,0.000006932207,0.00005929666,0.00005843319,0.000004278093],"category_scores_gemma":[0.00001250694,0.00008157648,0.00001193146,0.00009981392,0.0000176409,0.000002434829,0.00006084408,0.00001467149,0.000003162762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002261605,"about_ca_system_score_gemma":0.0002360227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001588622,"about_ca_topic_score_gemma":0.0002861748,"domain_scores_codex":[0.9994232,0.00001277536,0.0001761131,0.0001895571,0.00008508654,0.000113239],"domain_scores_gemma":[0.9997572,0.000001633416,0.00004507451,0.0001149544,0.00004921701,0.00003189738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001982996,0.00003843576,0.003343702,0.00001871269,0.00001518723,0.000003444259,0.0002803767,0.0001341703,0.9850436,0.0002185815,0.00001346929,0.01087049],"study_design_scores_gemma":[0.0004146623,0.00005384226,0.02284656,0.00001244716,0.000002632356,0.000005939461,0.0001273438,0.000002329489,0.9692984,0.0001490263,0.006988014,0.0000988532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997792,0.00110175,0.0006628398,0.00006758862,0.00007724511,0.000130545,0.000002010576,0.00000551486,0.0001604743],"genre_scores_gemma":[0.9817518,0.0002970347,0.01771171,0.00005469581,0.00002183956,0.00002689237,0.0000285953,0.000009173788,0.00009827947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01950286,"threshold_uncertainty_score":0.3326592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824606806640505,"score_gpt":0.2233344951588077,"score_spread":0.2175098883521672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}