{"id":"W2169965735","doi":"10.1101/gad.1192704","title":"Collaboration of Brca1 and Chk2 in tumorigenesis","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National University of Singapore; Amgen","keywords":"Biology; DNA damage; Checkpoint Kinase 2; Carcinogenesis; Context (archaeology); Cell biology; Phosphorylation; Cancer research; Signal transduction; Suppressor; DNA; Cancer; Genetics; Protein-Serine-Threonine Kinases; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002933608,0.0005557844,0.0002779565,0.0004632291,0.0004592037,0.0006675829,0.0002426392,0.0003963806,0.00135135],"category_scores_gemma":[0.0002666573,0.0002332857,0.0001492244,0.0002028053,0.0002524396,0.0004478763,0.0006805832,0.0003608254,0.0005047897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006886524,"about_ca_system_score_gemma":0.0005122073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005466369,"about_ca_topic_score_gemma":0.0008772313,"domain_scores_codex":[0.9997818,0.00004006782,0.00001033495,0.00004445669,0.00004955838,0.00007380664],"domain_scores_gemma":[0.9997633,0.00003177821,0.00004982697,0.00003594451,0.0000216959,0.00009741014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004890739,0.00003455587,0.003726806,0.0001078303,0.00001981855,0.0006648906,0.00004397404,0.0006389124,0.9849161,0.001608359,0.0003635842,0.00738613],"study_design_scores_gemma":[0.00006780088,0.0003024874,0.04443538,0.00002753502,0.00004531808,0.003308777,0.0001024906,0.004045405,0.9343255,0.001680985,0.01163228,0.00002594486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763196,0.01341612,0.003431249,0.0006543166,0.00005995486,0.00002164156,0.0003218619,0.0002726045,0.00550278],"genre_scores_gemma":[0.994468,0.001667638,0.0009764,0.0000536135,0.00001757755,0.00001221208,0.0001775692,0.00001345187,0.0026135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135135,"threshold_uncertainty_score":0.004996598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005824606806640505,"score_gpt":0.2233344951588077,"score_spread":0.2175098883521672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}