{"id":"W2169991618","doi":"10.1126/scisignal.2000546","title":"Eukaryotic Protein Domains as Functional Units of Cellular Evolution","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; Mount Sinai Hospital","funders":"","keywords":"Biology; Protein domain; Chromatin; Proteome; Architecture domain; Computational biology; Cell biology; Function (biology); Epigenetics; Domain (mathematical analysis); Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003752309,0.0001804012,0.0002149142,0.0006746861,0.0005619359,0.0006236715,0.0002764748,0.0003096053,0.0004837741],"category_scores_gemma":[0.0007060149,0.0001244652,0.0001607296,0.0008547942,0.0009495377,0.000933763,0.0007963864,0.0003891119,0.0001226993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005007557,"about_ca_system_score_gemma":0.0002521379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003324353,"about_ca_topic_score_gemma":0.0003662425,"domain_scores_codex":[0.9997473,0.0000800405,0.00001766221,0.00006535196,0.00004897988,0.00004063232],"domain_scores_gemma":[0.9997279,0.00006600031,0.00008453782,0.00004969765,0.00003007773,0.00004186909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005533501,0.00004702233,0.04607118,0.0004139839,0.0001100685,0.0005386486,0.001225164,0.006250615,0.6473822,0.1648944,0.0004924302,0.132021],"study_design_scores_gemma":[0.0001187752,0.00095711,0.3808864,0.0002523403,0.0003303734,0.00538987,0.003060906,0.05143356,0.2333377,0.2150204,0.109017,0.0001955524],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589772,0.003661064,0.03115323,0.000234426,0.00002086499,0.00003017192,0.000199699,0.00008899352,0.005634359],"genre_scores_gemma":[0.9826084,0.0009983396,0.01539806,0.00006142441,0.00001441012,0.00003059575,0.0002285853,0.00001851268,0.0006415818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006746861,"threshold_uncertainty_score":0.003633261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987859976724781,"score_gpt":0.2557522376385124,"score_spread":0.2358736378712646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}