{"id":"W2169991618","doi":"10.1126/scisignal.2000546","title":"Eukaryotic Protein Domains as Functional Units of Cellular Evolution","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; Mount Sinai Hospital","funders":"","keywords":"Biology; Protein domain; Chromatin; Proteome; Architecture domain; Computational biology; Cell biology; Function (biology); Epigenetics; Domain (mathematical analysis); Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005100531,0.00006899571,0.0001152688,0.0001656796,0.0001487243,0.00001346812,0.00008334466,0.00002909168,0.0002741833],"category_scores_gemma":[0.00006427026,0.00005905914,0.00003499653,0.001010679,0.0001452921,0.0001326913,0.000009801108,0.0000839511,0.00001493507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000119946,"about_ca_system_score_gemma":0.0006376154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003204826,"about_ca_topic_score_gemma":8.207749e-7,"domain_scores_codex":[0.9989024,0.00001166292,0.0001488462,0.0001980245,0.0005391465,0.0001999475],"domain_scores_gemma":[0.9994427,0.000008216069,0.00006483632,0.000146616,0.0002402004,0.00009745308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006091093,0.00003565661,0.00007271115,0.000008533595,0.000003005159,0.000005154594,0.0001003259,0.0001477462,0.9569719,0.0409887,0.000005606987,0.001599768],"study_design_scores_gemma":[0.0006107547,0.0006605454,0.002682466,0.0001380005,0.00001295135,0.0000152523,0.0001966698,0.0009104229,0.9701468,0.02442947,0.0001185824,0.00007805706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604535,0.00020175,0.03716575,0.0003030855,0.000136551,0.0002449754,0.0000011904,0.00002933872,0.001463937],"genre_scores_gemma":[0.9978276,0.000001502146,0.001414023,0.0001824094,0.0001219825,0.000003424978,0.000001954524,0.000004151713,0.0004429016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03737423,"threshold_uncertainty_score":0.3002114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987859976724781,"score_gpt":0.2557522376385124,"score_spread":0.2358736378712646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}