{"id":"W2169992693","doi":"10.1128/jvi.01334-14","title":"Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia","year":2014,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Massachusetts General Hospital","keywords":"Viremia; Biology; Downregulation and upregulation; Viral load; Immunology; Virology; Infectivity; Human leukocyte antigen; Immune system; Virus; Gene; Genetics; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134884,0.0002960751,0.0002139067,0.0002837064,0.0002030096,0.0002921943,0.0001884613,0.000341926,0.0015126],"category_scores_gemma":[0.001172487,0.00008757579,0.0000671432,0.0001555421,0.0002553368,0.0001586724,0.0001460981,0.0003144017,0.0001486411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553293,"about_ca_system_score_gemma":0.00008772867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005879483,"about_ca_topic_score_gemma":0.0003882413,"domain_scores_codex":[0.9998809,0.00001707178,0.00001293184,0.00003345232,0.00002507339,0.00003058843],"domain_scores_gemma":[0.9992917,0.0002235176,0.0002624808,0.00004328065,0.00006883754,0.0001102553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001835326,0.0002413976,0.6056648,0.00007605871,0.00005448064,0.0008416841,0.000237708,0.0002830203,0.374292,0.000123236,0.0001278576,0.01622235],"study_design_scores_gemma":[0.00001671919,0.0007252806,0.9640576,0.000007027421,0.00003163698,0.003444871,0.00008276952,0.0005978093,0.03048878,0.00004721271,0.0004942511,0.000006150095],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995516,0.0001490612,0.0001447623,0.000006523826,9.644029e-7,0.000002861438,0.00002552255,0.000003645608,0.0001151347],"genre_scores_gemma":[0.9994815,0.00005424724,0.0002082693,0.00000620931,0.000003789392,0.000003068222,0.00009450661,0.000001578189,0.000146883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015126,"threshold_uncertainty_score":0.005060136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007034321241698751,"score_gpt":0.2196919188911277,"score_spread":0.212657597649429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}