{"id":"W2170061118","doi":"10.1093/nass/nrn037","title":"In vitro selection of a DNAzyme with three modified nucleotides","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Deoxyribozyme; In vitro; Nucleotide; Divalent; Selection (genetic algorithm); Chemistry; Biochemistry; Biophysics; Combinatorial chemistry; Biology; Computer science; DNA; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007471951,0.0001793289,0.0002407303,0.00009009396,0.00008841611,0.000008413615,0.0001229282,0.0001415564,0.000002629546],"category_scores_gemma":[0.0000149009,0.0001470659,0.00007434513,0.0002458506,0.0002783404,0.00002011577,0.00005110935,0.0000901077,9.794362e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001972721,"about_ca_system_score_gemma":0.00004745401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004780395,"about_ca_topic_score_gemma":0.0001420379,"domain_scores_codex":[0.9990692,0.00003126695,0.0002328078,0.0003115376,0.0001412762,0.0002139553],"domain_scores_gemma":[0.9994778,0.000005283526,0.000114452,0.000253872,0.0001078343,0.00004077088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007766608,0.00007107604,0.003725392,0.00001421286,0.00003992879,0.000008632593,0.00005624536,0.00004865771,0.9948834,0.00006760849,0.0001298349,0.0001784005],"study_design_scores_gemma":[0.0003236269,0.0005073675,0.001976709,0.00001532313,0.00001975388,0.0001417573,0.00004449388,0.0001028545,0.9954347,0.00009411327,0.001144611,0.0001946796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974496,0.00004779432,0.001127192,0.000257758,0.00002722145,0.000125633,0.00001044648,0.00004732989,0.0009070024],"genre_scores_gemma":[0.9885404,0.0001834421,0.01065232,0.00009471658,0.00007338152,0.000009687117,0.00002822484,0.0000262226,0.0003916105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009525125,"threshold_uncertainty_score":0.5997174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007894962774680754,"score_gpt":0.2224734713707024,"score_spread":0.2145785085960217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}