{"id":"W2170061118","doi":"10.1093/nass/nrn037","title":"In vitro selection of a DNAzyme with three modified nucleotides","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Deoxyribozyme; In vitro; Nucleotide; Divalent; Selection (genetic algorithm); Chemistry; Biochemistry; Biophysics; Combinatorial chemistry; Biology; Computer science; DNA; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004197499,0.0005344021,0.0004550582,0.0001380658,0.0001314384,0.0004139072,0.0004357035,0.0005355224,0.00102814],"category_scores_gemma":[0.0006187096,0.0002673115,0.0002638195,0.0001864007,0.0002028923,0.0001425272,0.0003494023,0.0008775686,0.0007584824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001930791,"about_ca_system_score_gemma":0.0001843968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002958031,"about_ca_topic_score_gemma":0.0005157121,"domain_scores_codex":[0.999617,0.00009209902,0.0000418823,0.00009495154,0.0001055087,0.00004866635],"domain_scores_gemma":[0.9994742,0.0001797657,0.00009708432,0.00007295911,0.00006771453,0.0001083108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002306212,0.000007277338,0.00004584201,0.0000087285,0.000002118305,0.00002068253,0.00000874901,0.00003846959,0.9994254,0.00003029201,0.000006277317,0.0003829972],"study_design_scores_gemma":[0.00000541143,0.00006678959,0.0001924998,0.000001754266,0.000006598916,0.00009011683,0.000004104963,0.0002539229,0.9987209,0.000007743692,0.0006471967,0.000003013299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635731,0.0006234096,0.03375713,0.00009116176,0.00008465358,0.0001261736,0.0002726762,0.0002487808,0.001222978],"genre_scores_gemma":[0.9431644,0.00052709,0.04989811,0.00008806815,0.00001681929,0.0001189456,0.0008952953,0.0001802159,0.005110976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102814,"threshold_uncertainty_score":0.003439486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007894962774680754,"score_gpt":0.2224734713707024,"score_spread":0.2145785085960217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}