{"id":"W2170070436","doi":"10.1128/jvi.01310-06","title":"M-T5, the Ankyrin Repeat, Host Range Protein of Myxoma Virus, Activates Akt and Can Be Functionally Replaced by Cellular PIKE-A","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"School of Medicine, Emory University","keywords":"Biology; Ankyrin repeat; Protein kinase B; Myxoma virus; Pike; Cancer cell; Cell culture; Transfection; Proto-Oncogene Proteins c-akt; Phosphorylation; Molecular biology; Cell biology; Virus; Cancer; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008966686,0.0003167705,0.0001295309,0.0001131802,0.0001522656,0.0002646728,0.0001866958,0.0002518196,0.0008718171],"category_scores_gemma":[0.00009505329,0.0001135763,0.0002962431,0.00009770897,0.0001895852,0.0001821919,0.0001827447,0.0003968599,0.000259444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003871091,"about_ca_system_score_gemma":0.0001844978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007472599,"about_ca_topic_score_gemma":0.0009665212,"domain_scores_codex":[0.9998883,0.00002008306,0.00001380075,0.00001949657,0.0000281941,0.00003002174],"domain_scores_gemma":[0.9999497,0.000009537122,0.00001550365,0.000007676957,0.00000253494,0.00001514192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004520495,0.00001331092,0.0003463362,0.00002153402,0.00000444928,0.00006106287,0.000009434258,0.00004070388,0.9988021,0.0002156501,0.00002443653,0.0004158804],"study_design_scores_gemma":[0.00001230468,0.0002508228,0.00415459,0.000005301443,0.00001403258,0.0006541674,0.00002805306,0.001050474,0.9912325,0.00005405414,0.002540661,0.000003120715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969891,0.0005956433,0.0013477,0.00003673885,0.00001380082,0.00001367735,0.0001404372,0.00002914962,0.0008338933],"genre_scores_gemma":[0.997505,0.0002190528,0.00101232,0.0000166227,0.00000293922,0.00001170835,0.0002958798,0.000005406894,0.0009310962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008718171,"threshold_uncertainty_score":0.002916515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007899378982060251,"score_gpt":0.238382713252824,"score_spread":0.2304833342707638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}