{"id":"W2170213289","doi":"10.1128/jb.186.10.2973-2983.2004","title":"Assembly of the MexAB-OprM Multidrug Efflux System of <i>Pseudomonas aeruginosa</i> : Identification and Characterization of Mutations in <i>mexA</i> Compromising MexA Multimerization and Interaction with MexB","year":2004,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Foundation","keywords":"Efflux; Biology; Bacterial outer membrane; Mutation; Biochemistry; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005661,0.0002332054,0.0001498878,0.0001983432,0.0002058725,0.0003106546,0.0002578906,0.0002258556,0.0004692034],"category_scores_gemma":[0.0002652455,0.0001890783,0.0001796453,0.0001297002,0.0001557821,0.0001256485,0.0002195394,0.0004875168,0.000267391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004186422,"about_ca_system_score_gemma":0.0002190956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002789099,"about_ca_topic_score_gemma":0.002150138,"domain_scores_codex":[0.9998325,0.00002455963,0.00001882873,0.00002782164,0.00005826083,0.00003800132],"domain_scores_gemma":[0.9998746,0.00001120449,0.00004217703,0.00001078932,0.0000169869,0.00004418202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001723253,0.00001731395,0.0007338387,0.000007187047,0.000003198599,0.00008353838,0.0000271084,0.00005713569,0.9987078,0.00002673974,0.00001913153,0.0002997642],"study_design_scores_gemma":[0.0000159367,0.0002988193,0.07935003,0.00001789421,0.00003348444,0.00177581,0.0002231438,0.003322121,0.9126443,0.00007853039,0.002222753,0.00001726718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990583,0.00007081261,0.0003697071,0.00003911442,0.000002840333,0.00001044978,0.0001152205,0.0000131519,0.000320371],"genre_scores_gemma":[0.9974705,0.00009196009,0.0009640198,0.0000342045,0.000002730537,0.00001636805,0.0007063397,0.00001991462,0.0006939133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002789099,"threshold_uncertainty_score":0.005545676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00634887069964234,"score_gpt":0.2312007196190605,"score_spread":0.2248518489194181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}