{"id":"W2170213289","doi":"10.1128/jb.186.10.2973-2983.2004","title":"Assembly of the MexAB-OprM Multidrug Efflux System of <i>Pseudomonas aeruginosa</i> : Identification and Characterization of Mutations in <i>mexA</i> Compromising MexA Multimerization and Interaction with MexB","year":2004,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Foundation","keywords":"Efflux; Biology; Bacterial outer membrane; Mutation; Biochemistry; Escherichia coli; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003098129,0.0001220234,0.0003459464,0.0001134491,0.000038252,0.0000114695,0.0001169407,0.0001202671,8.958119e-7],"category_scores_gemma":[0.00008157267,0.00009159258,0.00004962438,0.0001315785,0.000223653,0.0000431604,0.00004443706,0.00009661764,8.545994e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000345774,"about_ca_system_score_gemma":0.000088792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004169335,"about_ca_topic_score_gemma":0.00003406229,"domain_scores_codex":[0.9986584,0.0001689661,0.0008052446,0.0001592762,0.0001123019,0.00009580897],"domain_scores_gemma":[0.9978797,0.0000396039,0.001587082,0.0001701437,0.0002937044,0.00002975046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002961838,0.00006974774,0.05006923,0.000156538,0.00005662161,9.067462e-7,0.0003577666,0.0002509168,0.9483556,0.00005220115,4.901528e-7,0.0003338617],"study_design_scores_gemma":[0.0008698569,0.0001833938,0.4296178,0.0002852528,0.000043223,0.0001148806,0.0002769213,0.0001143566,0.5684204,0.000005856152,0.0000111187,0.0000569603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939045,0.00005637332,0.005511802,0.00007871904,0.0001851781,0.0002236123,0.0000254395,0.000001943268,0.00001248864],"genre_scores_gemma":[0.9984769,0.0001259346,0.00127433,0.00001039003,0.00003870611,0.000001812454,0.00005341093,0.00001294122,0.000005636112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3799351,"threshold_uncertainty_score":0.3735037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00634887069964234,"score_gpt":0.2312007196190605,"score_spread":0.2248518489194181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}