{"id":"W2170245801","doi":"10.1677/joe.0.1720333","title":"Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells","year":2002,"lang":"en","type":"article","venue":"Journal of Endocrinology","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Hôtel-Dieu de Montréal","funders":"National Institutes of Health; Medical Research Council Canada; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; Kidney Foundation of Canada","keywords":"Internal medicine; Endocrinology; MAPK/ERK pathway; Insulin; Angiotensin II; Renin–angiotensin system; Signal transduction; Kidney; Diabetes mellitus; Diabetic nephropathy; Gene expression; Receptor; Biology; Chemistry; Medicine; Gene; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141307,0.0003310182,0.0004152691,0.0002817782,0.0001408488,0.0003558407,0.0001249472,0.0001814788,0.001368696],"category_scores_gemma":[0.00008730297,0.0002063208,0.0004458697,0.0003543983,0.0001953596,0.0001860054,0.0001794809,0.0007557624,0.0004159824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433994,"about_ca_system_score_gemma":0.000195496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086655,"about_ca_topic_score_gemma":0.001216449,"domain_scores_codex":[0.9997551,0.0000280295,0.00002987244,0.00004894067,0.00006734054,0.00007072225],"domain_scores_gemma":[0.9998746,0.00001923176,0.00003066546,0.00002277738,0.00001664443,0.00003601052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003191393,0.00005671864,0.0003773829,0.00002907577,0.000006354983,0.00006837035,0.00002374558,0.0000187572,0.9983717,0.00003533974,0.00002681142,0.0006666517],"study_design_scores_gemma":[0.00005768763,0.001757577,0.03757532,0.0000109576,0.00006007834,0.0004435777,0.0001564086,0.0005465276,0.9566594,0.00008799796,0.002630699,0.00001371315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949527,0.001896717,0.0009762878,0.0000766228,0.00006478072,0.00002025552,0.0004158148,0.00004780231,0.001549097],"genre_scores_gemma":[0.9926894,0.002068017,0.001200726,0.00013193,0.000032862,0.00006696378,0.001035445,0.00001755261,0.002756967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368696,"threshold_uncertainty_score":0.004578769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02483151417227187,"score_gpt":0.2529001364341614,"score_spread":0.2280686222618896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}