{"id":"W2170257753","doi":"10.1093/toxsci/kfp160","title":"Effects of 18 Perfluoroalkyl Compounds on mRNA Expression in Chicken Embryo Hepatocyte Cultures","year":2009,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Perfluorooctane; Chemistry; Messenger RNA; Cytochrome P450; Biochemistry; Hepatocyte; Lipid metabolism; Metabolism; Biology; Gene; Sulfonate; Sodium; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006253574,0.0001841951,0.0002761208,0.00007108637,0.0002679963,0.00005277807,0.000818443,0.0001421794,0.001645072],"category_scores_gemma":[0.0001591816,0.0001117227,0.00007637905,0.0007222532,0.0009606613,0.0002464163,0.0001579649,0.0002728312,0.0001369539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255482,"about_ca_system_score_gemma":0.00001843341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007928686,"about_ca_topic_score_gemma":0.00006748226,"domain_scores_codex":[0.9975082,0.0002358637,0.0002678317,0.0005170185,0.0008916547,0.0005794419],"domain_scores_gemma":[0.9992714,0.0002940646,0.00008282785,0.0001647347,0.000006243515,0.0001807493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000124377,0.0006965289,0.04739834,0.000008752064,0.000001478486,0.00003402124,0.0004314003,0.0006901512,0.8830118,0.0002802401,0.002744375,0.0645786],"study_design_scores_gemma":[0.0004308738,0.001782489,0.7220336,0.00005180302,0.000002076256,0.000003146543,0.00006719212,0.0006950035,0.2706807,0.001741007,0.002314336,0.0001977144],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9363387,0.00138108,0.000008233655,0.0003689362,0.00006925981,0.0003133801,0.000001946134,0.00003406284,0.06148437],"genre_scores_gemma":[0.9982719,0.0002330346,0.0005590914,0.0005136215,0.00003426713,0.0000202173,0.000001105522,0.000002895813,0.0003639019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6746353,"threshold_uncertainty_score":0.9992676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02709395213488653,"score_gpt":0.3183175463911999,"score_spread":0.2912235942563134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}