{"id":"W2170281192","doi":"10.1016/j.bmc.2010.08.048","title":"Synthesis and in vitro antiviral activities of 3′-fluoro (or chloro) and 2′,3′-difluoro 2′,3′-dideoxynucleoside analogs against hepatitis B and C viruses","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Virology; Hepatitis C virus; Hepatitis B virus; Virus; In vitro; Chemistry; Duck hepatitis B virus; Hepatitis; Hepatitis B; Cytotoxicity; Hepadnaviridae; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002599893,0.0004353713,0.0004187418,0.0002481165,0.0002588686,0.0002386812,0.0003423334,0.000304031,0.001696154],"category_scores_gemma":[0.0002193366,0.0002374903,0.0003009963,0.0002076985,0.000173021,0.00017794,0.0001333733,0.0003709598,0.0003604143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002631402,"about_ca_system_score_gemma":0.0002681449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008119445,"about_ca_topic_score_gemma":0.0009484328,"domain_scores_codex":[0.9998566,0.00003871638,0.00001852888,0.00002421273,0.00002091999,0.00004105817],"domain_scores_gemma":[0.9998827,0.00003432962,0.00002260654,0.00001527992,0.00001403834,0.00003095548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008930831,0.000110928,0.0002312255,0.000143824,0.00001585437,0.0002212289,0.00006269271,0.001175168,0.9895661,0.0004080193,0.000168595,0.007003248],"study_design_scores_gemma":[0.0001380096,0.001623448,0.001096668,0.00001376417,0.00003382604,0.0002705194,0.00001747909,0.0005546177,0.9920036,0.00005805385,0.004175284,0.00001468877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98035,0.005920437,0.004621902,0.0001290372,0.0001235325,0.0001332634,0.001262747,0.000101478,0.007357699],"genre_scores_gemma":[0.9909373,0.00199788,0.003752193,0.00008900119,0.00002828035,0.0000699844,0.001298993,0.00001885479,0.001807566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696154,"threshold_uncertainty_score":0.005674124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772423969518581,"score_gpt":0.2810974499748294,"score_spread":0.2633732102796436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}