{"id":"W2170323442","doi":"10.1039/c3cp44539a","title":"Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage","year":2013,"lang":"en","type":"article","venue":"Physical Chemistry Chemical Physics","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Università di Catania","keywords":"Membrane; Biophysics; Chemistry; Peptide; Lipid bilayer; Molecular dynamics; Chemical physics; Computational chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003670266,0.0001724254,0.0002696647,0.00002108029,0.00002941092,0.00001596279,0.000077323,0.0001288926,0.000008836906],"category_scores_gemma":[0.00004848601,0.0001715072,0.00007222329,0.0001423735,0.0002352858,0.00005626219,0.00004901748,0.0001250652,3.212207e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001390145,"about_ca_system_score_gemma":0.00004999346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002191181,"about_ca_topic_score_gemma":0.000001454604,"domain_scores_codex":[0.9990743,0.00001634346,0.0003287304,0.000250439,0.0001784103,0.0001517325],"domain_scores_gemma":[0.9994566,0.00002538298,0.0001208375,0.0001631828,0.0001467043,0.0000872388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003555736,0.0001657379,0.000246506,0.0003707047,0.00001811705,9.090254e-8,0.0002283176,0.004688174,0.9931861,0.0001229463,0.000003517121,0.0009343009],"study_design_scores_gemma":[0.0006010497,0.00001644457,0.0005624831,0.00003581847,0.00004248789,0.000001863533,0.00005660382,0.2297461,0.7683548,0.0004454937,0.000004495325,0.000132342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982055,0.00001360245,0.001160508,0.00006140328,0.000007376559,0.0001824792,0.0001085197,0.000008271584,0.0002522876],"genre_scores_gemma":[0.9984607,0.00002496473,0.0006306396,0.00002156392,0.0001369885,0.00001725203,0.0006690645,0.00001473282,0.00002410652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2250579,"threshold_uncertainty_score":0.6993861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459858105115403,"score_gpt":0.2481824701504638,"score_spread":0.2335838890993097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}