{"id":"W2170324007","doi":"10.1083/jcb.200808124","title":"N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic","year":2009,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Endocytic cycle; Cell biology; Endosome; Biology; Glycosylation; Transmembrane protein; Endoplasmic-reticulum-associated protein degradation; Transport protein; Membrane protein; Ubiquitin; Chaperone (clinical); Glycan; Glycoprotein; Proteostasis; Protein folding; Endoplasmic reticulum; Endocytosis; Biochemistry; Intracellular; Unfolded protein response; Cell; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005295555,0.00008779576,0.0002343659,0.0000444241,0.00002526594,0.000002615215,0.00008966547,0.00009931009,0.000006312141],"category_scores_gemma":[0.00002809253,0.00006022138,0.00004684611,0.00003889474,0.0001214864,0.000003726516,0.00001265775,0.0001010031,6.777427e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008219431,"about_ca_system_score_gemma":0.00003545295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007508497,"about_ca_topic_score_gemma":0.0001157282,"domain_scores_codex":[0.9993005,0.0001356569,0.0002966862,0.00009885873,0.00004343914,0.0001248778],"domain_scores_gemma":[0.9995599,0.00004017954,0.0002140961,0.0001039391,0.00004068069,0.00004124229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002939934,0.0000323149,0.01458433,0.00002621698,0.000007991728,0.000005760585,0.000231207,0.00002304062,0.9831145,0.000001457875,6.390282e-7,0.001678509],"study_design_scores_gemma":[0.0009323644,0.0008977178,0.03807542,0.0000310209,0.00004733394,0.00007647036,0.0002927696,0.0001387884,0.9589564,0.00005350107,0.0004046794,0.00009352098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958756,0.003792835,0.0000709404,0.00003155214,0.00004894606,0.00006800933,0.000005032977,0.000001124976,0.0001059496],"genre_scores_gemma":[0.9978012,0.002060503,0.00004165572,0.0000325463,0.00004208627,2.764162e-7,0.000009769692,0.000004148222,0.000007801589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02415813,"threshold_uncertainty_score":0.2455757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099755713344112,"score_gpt":0.2292126436808581,"score_spread":0.218215086547417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}