{"id":"W2170332740","doi":"10.1136/jmg.2009.074237","title":"Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research","year":2010,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":542,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"BC Cancer Agency; University College London Hospitals NHS Foundation Trust; Radboud Universiteit; Memorial Sloan-Kettering Cancer Center; Institut National de la Santé et de la Recherche Médicale; Massachusetts General Hospital; University of Leeds; Cancer Research UK; University of Nottingham; Università degli Studi di Siena; Nottingham University Hospitals NHS Trust; University of Otago","keywords":"Medicine; Breast cancer; Cancer; Invasive lobular carcinoma; Genetic testing; Germline mutation; Family history; Mammography; General surgery; Internal medicine; Oncology; Pathology; Mutation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001993034,0.0001047533,0.0001946973,0.0001004797,0.0001131223,0.00002010844,0.0002168852,0.0004139507,0.00002173489],"category_scores_gemma":[0.0008057188,0.00008665959,0.0001349042,0.0001242333,0.0001958477,0.000001791267,0.00008838296,0.0003927497,3.07897e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001612333,"about_ca_system_score_gemma":0.0003203345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004795474,"about_ca_topic_score_gemma":0.0001348929,"domain_scores_codex":[0.9982882,0.00008083445,0.0006701347,0.0002123168,0.0005168961,0.0002316462],"domain_scores_gemma":[0.9979594,0.0001122996,0.0002033219,0.0001881897,0.001245918,0.0002908684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006093436,0.0002110861,0.002163441,0.00006864638,0.0004128416,0.00001103397,0.00001672193,0.00008664896,0.0123139,0.00005051929,0.6424989,0.341557],"study_design_scores_gemma":[0.003553876,0.0007917318,0.006376577,0.00004589938,0.0001452504,0.0002329615,0.0001476161,0.002098804,0.002718339,0.0002337308,0.9835321,0.0001230898],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533576,0.01865873,0.00338927,0.01961647,0.004392972,0.0004942463,0.00006125503,0.000005468158,0.00002403203],"genre_scores_gemma":[0.4055123,0.3341166,0.1697545,0.002256516,0.08476405,0.0002316909,0.0003062427,0.0001996962,0.002858343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5478452,"threshold_uncertainty_score":0.3533876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0898694985927116,"score_gpt":0.4592207861941303,"score_spread":0.3693512876014187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}