{"id":"W2170360953","doi":"10.1074/jbc.m005776200","title":"Mutational Analysis of the CYP2B2 Phenobarbital Response Unit and Inhibitory Effect of the Constitutive Androstane Receptor on Phenobarbital Responsiveness","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Medical Research Council","keywords":"Constitutive androstane receptor; Retinoic acid; Enhancer; Molecular biology; Transfection; Reporter gene; Transcription (linguistics); Androstane; Transcription factor; Phenobarbital; Biology; Context (archaeology); Nuclear receptor; Chemistry; Gene; Cell biology; Biochemistry; Gene expression; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485855,0.0003583398,0.0002187433,0.0001727271,0.0001022524,0.0001234481,0.0001590165,0.0001796579,0.001727779],"category_scores_gemma":[0.0001763743,0.0001560183,0.0002777766,0.0001131539,0.0001794174,0.00007065853,0.0001516573,0.0003220258,0.0006887216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001890141,"about_ca_system_score_gemma":0.0001536936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006317351,"about_ca_topic_score_gemma":0.0009437752,"domain_scores_codex":[0.999845,0.00005411348,0.00001501484,0.00002269148,0.00003964044,0.0000234586],"domain_scores_gemma":[0.9998179,0.00006759385,0.00004749679,0.00002148272,0.00001520688,0.00003021355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006501179,0.00001864869,0.0001290986,0.00001377817,0.000003229067,0.00007263,0.000006974838,0.00008173662,0.9990886,0.00006215111,0.000008765593,0.0004493633],"study_design_scores_gemma":[0.00001641958,0.0001787764,0.005331762,0.000006981497,0.00001679987,0.000500844,0.00001510823,0.001256557,0.9912084,0.00002381283,0.001438249,0.000006161843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994622,0.000363141,0.003659332,0.00004567432,0.00001018247,0.00003289343,0.000259435,0.00007189253,0.0009353316],"genre_scores_gemma":[0.9962834,0.00022212,0.001749443,0.00003087006,0.000005836475,0.00002928561,0.0005351041,0.00004338994,0.001100591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727779,"threshold_uncertainty_score":0.005780041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596279724641665,"score_gpt":0.3726882575481396,"score_spread":0.3267254603017229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}