{"id":"W2170360953","doi":"10.1074/jbc.m005776200","title":"Mutational Analysis of the CYP2B2 Phenobarbital Response Unit and Inhibitory Effect of the Constitutive Androstane Receptor on Phenobarbital Responsiveness","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Medical Research Council","keywords":"Constitutive androstane receptor; Retinoic acid; Enhancer; Molecular biology; Transfection; Reporter gene; Transcription (linguistics); Androstane; Transcription factor; Phenobarbital; Biology; Context (archaeology); Nuclear receptor; Chemistry; Gene; Cell biology; Biochemistry; Gene expression; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001684357,0.0001992392,0.0005320812,0.0000632716,0.0001559774,0.000007319924,0.0003715553,0.0002816053,0.001112914],"category_scores_gemma":[0.0007730109,0.0001021097,0.0003922642,0.0005078726,0.001232462,0.00003417331,0.00008807131,0.0007375603,0.000001861788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003703589,"about_ca_system_score_gemma":0.0001820089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001381469,"about_ca_topic_score_gemma":2.125115e-7,"domain_scores_codex":[0.9973001,0.001454991,0.0005894151,0.0001799313,0.0002805479,0.0001949964],"domain_scores_gemma":[0.9967775,0.002166761,0.0005406659,0.0001641917,0.0002106661,0.0001401983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01657822,0.0002401578,0.02184858,0.0000289789,0.001003337,0.00002250059,0.0001973449,0.002004176,0.9556377,0.00003740109,0.0001215125,0.002280106],"study_design_scores_gemma":[0.002063644,0.0003450394,0.05682507,0.0000422808,0.001018548,0.00007884487,0.00007864898,0.0001303065,0.9340467,0.0001189096,0.005122007,0.0001299661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966099,0.001173883,0.000001847845,0.0003147098,0.0002986982,0.0001485831,0.000394636,0.0000040801,0.001053607],"genre_scores_gemma":[0.9991332,0.0002077746,0.00002068786,0.0003110903,0.000141304,0.000003597275,0.000006268092,0.000005923108,0.0001701604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03497649,"threshold_uncertainty_score":0.9998002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596279724641665,"score_gpt":0.3726882575481396,"score_spread":0.3267254603017229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}