{"id":"W2170373770","doi":"10.1200/jco.2009.22.7504","title":"Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Charles-Le Moyne","funders":"","keywords":"Medicine; Anthracycline; Metastatic breast cancer; Tolerability; Internal medicine; Breast cancer; Regimen; Cyclophosphamide; Cardiotoxicity; Surgery; Doxorubicin; Chemotherapy; Oncology; Neutropenia; Phases of clinical research; Taxane; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002037567,0.001435298,0.00141216,0.0002747987,0.0003402363,0.0007740282,0.0008385054,0.001397289,0.003098929],"category_scores_gemma":[0.001030755,0.0004557938,0.0008630513,0.0002893156,0.0009295528,0.000609795,0.0003160266,0.003024966,0.000746476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008449458,"about_ca_system_score_gemma":0.001526267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000829496,"about_ca_topic_score_gemma":0.001751496,"domain_scores_codex":[0.9995091,0.0002697069,0.00002198437,0.00008788878,0.00003260502,0.00007855896],"domain_scores_gemma":[0.9990639,0.0001783737,0.0002259698,0.00006423712,0.0000412374,0.0004263792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8348834,0.05479733,0.005689884,0.0006085904,0.001003844,0.0002948803,0.0002560118,0.001918437,0.03814157,0.0001975096,0.002875496,0.05933301],"study_design_scores_gemma":[0.69318,0.2949464,0.006528578,0.0000270126,0.0002264809,0.0002041681,0.0000260631,0.0008845346,0.00279792,0.00007593296,0.001089056,0.00001379607],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938583,0.001636256,0.0004889716,0.0005199866,0.0001192862,0.001987674,0.000447707,0.00007811497,0.0008636818],"genre_scores_gemma":[0.9904838,0.001233923,0.001502274,0.0007373428,0.0001911663,0.002392996,0.001664203,0.00002709138,0.001767208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003098929,"threshold_uncertainty_score":0.0107758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1339295060981442,"score_gpt":0.4992566936739258,"score_spread":0.3653271875757816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}