{"id":"W2170373770","doi":"10.1200/jco.2009.22.7504","title":"Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Charles-Le Moyne","funders":"","keywords":"Medicine; Anthracycline; Metastatic breast cancer; Tolerability; Internal medicine; Breast cancer; Regimen; Cyclophosphamide; Cardiotoxicity; Surgery; Doxorubicin; Chemotherapy; Oncology; Neutropenia; Phases of clinical research; Taxane; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001465147,0.000401499,0.003853191,0.0002266774,0.00007679714,0.000004355758,0.0002088745,0.0003125055,0.0002391899],"category_scores_gemma":[0.0003776995,0.0002235544,0.0006590635,0.0003095473,0.000441955,0.000168304,0.00002153293,0.0006420072,5.39394e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898016,"about_ca_system_score_gemma":0.0018258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000119344,"about_ca_topic_score_gemma":0.0003731459,"domain_scores_codex":[0.9947332,0.0003493283,0.003676044,0.0003736509,0.0004389779,0.0004287678],"domain_scores_gemma":[0.9913203,0.002145085,0.004456506,0.0002825923,0.001399892,0.0003955848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7371123,0.04866835,0.004530724,0.0001080747,0.002873743,0.0004615065,0.000367109,0.0001954508,0.002437604,0.00000512422,0.0003850418,0.202855],"study_design_scores_gemma":[0.5728781,0.3978991,0.01439564,0.0006744664,0.003485023,0.0004255814,0.0000815599,0.0006514793,0.005604726,0.00003440369,0.003666446,0.0002035849],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977602,0.004200695,0.0001754374,0.01491606,0.0005796363,0.00231178,0.0001257598,0.00001866642,0.00006996141],"genre_scores_gemma":[0.9643205,0.03020795,0.003225541,0.0008112342,0.00116316,0.00005229769,0.00003297604,0.00004263856,0.0001436317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3492307,"threshold_uncertainty_score":0.9116282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1339295060981442,"score_gpt":0.4992566936739258,"score_spread":0.3653271875757816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}