{"id":"W2170383569","doi":"10.1128/aac.01795-09","title":"The M230L Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation in HIV-1 Reverse Transcriptase Impairs Enzymatic Function and Viral Replicative Capacity","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Reverse transcriptase; Biology; Nevirapine; Efavirenz; Virology; RNase H; Polymerase; Mutant; Resistance mutation; Viral replication; DNA polymerase; Enzyme; Recombinant DNA; Molecular biology; Processivity; Nucleotidyltransferase; Etravirine; Mutation; Virus; RNA; Gene; Genetics; Biochemistry; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715062,0.0005049562,0.0003351395,0.0001366229,0.0002029165,0.0005435308,0.0002973602,0.000526721,0.001516085],"category_scores_gemma":[0.0003708378,0.0002089032,0.0004095271,0.0001282624,0.0003697299,0.0002424248,0.0002406392,0.0005933614,0.0008044584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003937022,"about_ca_system_score_gemma":0.0002491252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006954094,"about_ca_topic_score_gemma":0.0005569158,"domain_scores_codex":[0.9996636,0.0001152365,0.00003798544,0.00004692536,0.00008346075,0.0000528696],"domain_scores_gemma":[0.9997919,0.00004944577,0.00007382104,0.00002279444,0.00001394085,0.0000481546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651362,0.0001018123,0.0004478758,0.00002289275,0.00001468139,0.0001790711,0.00001948544,0.0001249565,0.996897,0.0001691674,0.00007180542,0.001786072],"study_design_scores_gemma":[0.00007285336,0.002129494,0.005608751,0.00001651215,0.00003721447,0.002525793,0.00005621935,0.001857901,0.9839911,0.0001222269,0.003561082,0.00002080437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979348,0.0006174836,0.000715494,0.00005357297,0.00001546033,0.00001667734,0.0001454614,0.00003585192,0.0004652513],"genre_scores_gemma":[0.9978724,0.0002797203,0.0009540587,0.00004732943,0.000009457583,0.00002157852,0.0001904488,0.00002138884,0.0006036145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516085,"threshold_uncertainty_score":0.005071759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00927124819867998,"score_gpt":0.2292119459778219,"score_spread":0.2199406977791419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}