{"id":"W2170516524","doi":"10.3390/genes2010081","title":"Looking into the Black Box: Insights into the Mechanisms of Somatic Cell Reprogramming","year":2011,"lang":"en","type":"article","venue":"Genes","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Stem Cell Network; Howard Hughes Medical Institute","keywords":"Reprogramming; Induced pluripotent stem cell; Epigenetics; Somatic cell; Biology; Chromatin; Transdifferentiation; Regenerative medicine; Computational biology; Epigenesis; Cell biology; Genetics; Stem cell; Cell; DNA methylation; Gene expression; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003625296,0.0001276799,0.0001142086,0.00003228908,0.0001663863,0.00002196419,0.0005613218,0.00009530895,0.00002090579],"category_scores_gemma":[0.0000359046,0.0000722718,0.00009535655,0.0001129788,0.0001887156,0.000003576099,0.0003743315,0.00008670894,0.00003165714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008843204,"about_ca_system_score_gemma":0.00004990678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002374874,"about_ca_topic_score_gemma":0.0001642158,"domain_scores_codex":[0.9989205,0.0001328988,0.0002182389,0.0002789999,0.0002193437,0.0002300036],"domain_scores_gemma":[0.9990012,0.00002258544,0.0001065587,0.0007378508,0.00008645482,0.00004534866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002040487,0.00004352622,0.0002771682,0.00006694708,0.00004290622,0.000003175705,0.004745727,0.00001603142,0.9847467,0.0002184331,0.0000671635,0.0097518],"study_design_scores_gemma":[0.0001347205,0.0001313188,0.0002109158,0.00001328732,0.00001934394,0.000002493887,0.001613976,0.0001501606,0.9874885,0.003612506,0.006524735,0.00009805201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866185,0.004042483,0.006568014,0.0001156651,0.0001013921,0.000316753,4.232078e-7,0.00001090041,0.002225875],"genre_scores_gemma":[0.9959829,0.0005028537,0.002615284,0.000079461,0.00007903993,0.00003194952,0.000008438087,0.00002100702,0.0006790385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009653747,"threshold_uncertainty_score":0.2947159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689566791166137,"score_gpt":0.2447244217141276,"score_spread":0.2278287538024663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}