{"id":"W2170516524","doi":"10.3390/genes2010081","title":"Looking into the Black Box: Insights into the Mechanisms of Somatic Cell Reprogramming","year":2011,"lang":"en","type":"article","venue":"Genes","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Stem Cell Network; Howard Hughes Medical Institute","keywords":"Reprogramming; Induced pluripotent stem cell; Epigenetics; Somatic cell; Biology; Chromatin; Transdifferentiation; Regenerative medicine; Computational biology; Epigenesis; Cell biology; Genetics; Stem cell; Cell; DNA methylation; Gene expression; Gene; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001540125,0.0005545327,0.0008689645,0.0010129,0.0005694499,0.001925469,0.0008209571,0.001413004,0.002330366],"category_scores_gemma":[0.000952975,0.0002754816,0.0005720943,0.0008333054,0.003254409,0.00525846,0.0008187125,0.004936889,0.001134386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001003526,"about_ca_system_score_gemma":0.001034195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000454904,"about_ca_topic_score_gemma":0.0004517384,"domain_scores_codex":[0.9995902,0.0001029673,0.00003242082,0.0000661642,0.0001658473,0.00004234238],"domain_scores_gemma":[0.9993559,0.0003869077,0.00005378445,0.0000622337,0.00009035067,0.00005092452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002955763,0.0001355882,0.00100706,0.004217644,0.0001195711,0.0009612468,0.001164836,0.002887002,0.138744,0.3717383,0.01381248,0.4649166],"study_design_scores_gemma":[0.0000326156,0.0004140906,0.001500155,0.001207348,0.0001036616,0.001841434,0.0007258076,0.003371595,0.05507075,0.4100132,0.5256284,0.00009093535],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01497997,0.7955303,0.1247452,0.04427417,0.003344706,0.00004718995,0.0002722353,0.0002911399,0.01651506],"genre_scores_gemma":[0.1253935,0.8171046,0.03759065,0.009510169,0.002303932,0.00007865199,0.0001926422,0.00009997471,0.007725894],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002330366,"threshold_uncertainty_score":0.008145034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689566791166137,"score_gpt":0.2447244217141276,"score_spread":0.2278287538024663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}