{"id":"W2170520945","doi":"10.1016/j.bmcl.2005.01.050","title":"Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Institut National de la Recherche Scientifique","funders":"","keywords":"Human cytomegalovirus; Chemistry; Stereochemistry; Chemical synthesis; In vitro; Cytomegalovirus; Combinatorial chemistry; Herpesviridae; Biochemistry; Virology; Virus; Viral disease; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617084,0.0003995432,0.0003145684,0.0001946178,0.0001891705,0.0002459339,0.0004907189,0.0002335897,0.001703072],"category_scores_gemma":[0.000133308,0.0002008597,0.0001925044,0.0001300896,0.0001192167,0.0002217033,0.000224013,0.0003690289,0.0005821951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615511,"about_ca_system_score_gemma":0.0002268021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004216837,"about_ca_topic_score_gemma":0.001429283,"domain_scores_codex":[0.999931,0.00001040954,0.000007736035,0.00001487515,0.00001674718,0.00001928138],"domain_scores_gemma":[0.9999591,0.000004840217,0.0000111552,0.000004526981,0.000007337946,0.00001288852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002442504,0.000104782,0.0001262588,0.0002877808,0.00002539072,0.0003329344,0.00009068311,0.002322196,0.9738051,0.001353205,0.0005608635,0.02074659],"study_design_scores_gemma":[0.0001813446,0.002398501,0.0009903685,0.00003318335,0.00005761754,0.0005544429,0.00002715246,0.002785736,0.9561625,0.0002542654,0.03652882,0.00002617475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9076925,0.01553226,0.05054787,0.0005287,0.0003083011,0.001117224,0.001662384,0.0005864349,0.02202429],"genre_scores_gemma":[0.9490986,0.01017858,0.02747096,0.0002468738,0.00006159431,0.0003940753,0.001490995,0.0000566878,0.0110018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001703072,"threshold_uncertainty_score":0.00569737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015203218540299,"score_gpt":0.2745062861545051,"score_spread":0.2543542539691021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}