{"id":"W2170522795","doi":"10.1016/j.cytogfr.2007.06.002","title":"Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response","year":2007,"lang":"en","type":"review","venue":"Cytokine & Growth Factor Reviews","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":242,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Interferon regulatory factors; Biology; TANK-binding kinase 1; Kinase; IκB kinase; Transcription factor; Phosphorylation; Interferon; Signal transduction; Promoter; Cell biology; Transcriptional regulation; Innate immune system; NF-κB; Gene; Genetics; Gene expression; Protein kinase A; Receptor; MAP kinase kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001030661,0.001241033,0.001707575,0.0009054971,0.0003029246,0.001349419,0.001551286,0.001280842,0.002598466],"category_scores_gemma":[0.0004919483,0.0003097293,0.0003513564,0.001125342,0.0008616992,0.001924141,0.0008156034,0.002445864,0.002772302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009349073,"about_ca_system_score_gemma":0.001189262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005770191,"about_ca_topic_score_gemma":0.0008440961,"domain_scores_codex":[0.999737,0.00003612012,0.00002956144,0.0000449903,0.0001224868,0.00002986418],"domain_scores_gemma":[0.99962,0.0001279586,0.00005244838,0.00001461478,0.0001208869,0.00006420988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002559567,0.00005827365,0.0001590883,0.005177588,0.00006294566,0.0003911398,0.00006667022,0.0004454029,0.01417439,0.01101971,0.02635367,0.9418351],"study_design_scores_gemma":[0.00005211615,0.00008952324,0.001131855,0.001159213,0.00006638807,0.001847938,0.00008629982,0.0001666181,0.002988813,0.006669103,0.9857123,0.00002993378],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003446504,0.9960557,0.0007186186,0.0005226568,0.0007514855,0.000004830854,0.00001109204,0.0000176927,0.001573178],"genre_scores_gemma":[0.001553893,0.9954736,0.000680098,0.0002374285,0.0008257732,0.000007276189,0.00002943209,0.000002941596,0.001189502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002598466,"threshold_uncertainty_score":0.008692741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07045438817607706,"score_gpt":0.3185669859803459,"score_spread":0.2481125978042689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}