{"id":"W2170559900","doi":"10.1038/ng.179","title":"Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease","year":2008,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":514,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; Mount Sinai Hospital; St. Michael's Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Cancer Research UK; PKD Foundation","keywords":"Biology; Frizzled; Cell biology; Transcription factor; Genetics; RNA interference; Signal transduction; Wnt signaling pathway; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006572033,0.0002112401,0.0001810372,0.00005598557,0.0001043071,0.00001193198,0.0001298108,0.0002443597,0.00001152815],"category_scores_gemma":[0.0002265741,0.000196039,0.00005848623,0.0001153481,0.0001551506,0.000002374781,0.0002091404,0.0001348832,0.00000351403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005134893,"about_ca_system_score_gemma":0.0001342861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000165748,"about_ca_topic_score_gemma":0.000001072982,"domain_scores_codex":[0.9988123,0.0000437918,0.0002131602,0.0004451795,0.0002368743,0.0002487407],"domain_scores_gemma":[0.998741,0.00001638672,0.00006527342,0.0003284982,0.0001436896,0.0007051364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003061589,0.000174429,0.1695345,0.0002336481,0.00003359257,0.00004525335,0.0001996134,0.0002285151,0.8236932,0.000009903732,0.005063281,0.0004779055],"study_design_scores_gemma":[0.00183321,0.0008000923,0.2938184,0.0001101915,0.0001496209,0.0000410142,0.00008106277,0.000198543,0.6693774,0.000099693,0.03281396,0.0006768585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871753,0.0109071,0.001107527,0.0001014398,0.0001409705,0.0002318125,0.0002170262,0.000009336739,0.0001094444],"genre_scores_gemma":[0.9953361,0.0008033607,0.002470626,0.0008084492,0.0001313377,0.000007997732,0.0001255227,0.00002851223,0.0002880667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543159,"threshold_uncertainty_score":0.7994237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004990224278685443,"score_gpt":0.2373025494928039,"score_spread":0.2323123252141185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}