{"id":"W2170592008","doi":"10.1161/01.atv.0000189158.28455.94","title":"A Novel Inhibitor of Oxidosqualene:Lanosterol Cyclase Inhibits Very Low–Density Lipoprotein Apolipoprotein B100 (ApoB100) Production and Enhances Low-Density Lipoprotein ApoB100 Catabolism Through Marked Reduction in Hepatic Cholesterol Content","year":2005,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Center for Research Resources; National Heart Foundation of Australia; F. Hoffmann-La Roche; Heart and Stroke Foundation of Canada","keywords":"Very low-density lipoprotein; Apolipoprotein B; Endocrinology; Internal medicine; Chylomicron; Cholesterol; LDL receptor; Chemistry; Lanosterol; Lipoprotein; Low-density lipoprotein; Catabolism; Lathosterol; Intermediate-density lipoprotein; Sterol; Biology; Metabolism; Campesterol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179042,0.0005151851,0.0004667544,0.0002225366,0.0001322548,0.0002118451,0.0002644211,0.0003088627,0.001604572],"category_scores_gemma":[0.00009140723,0.0001290849,0.0003383136,0.0001098549,0.0002541377,0.000171975,0.0001266211,0.000751378,0.0003456046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265584,"about_ca_system_score_gemma":0.0003117988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003803061,"about_ca_topic_score_gemma":0.00128567,"domain_scores_codex":[0.9999313,0.00000733945,0.000008075897,0.00001557139,0.00001663186,0.00002096665],"domain_scores_gemma":[0.9999228,0.00001048325,0.00002775538,0.000005143673,0.000008090506,0.00002568268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001182739,0.0003323806,0.0002857613,0.0001291358,0.00003394478,0.0001082004,0.00001222549,0.0001023973,0.9921933,0.0001025442,0.0001163478,0.005401003],"study_design_scores_gemma":[0.002022484,0.01304008,0.005966421,0.00002306042,0.0001667269,0.001093151,0.00003704318,0.0009577217,0.9684408,0.00005962657,0.008172297,0.00002063251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919949,0.003352102,0.00260785,0.0001971019,0.0000726842,0.0001083752,0.0003119957,0.0001020644,0.001252918],"genre_scores_gemma":[0.9888284,0.002910275,0.00401321,0.0001375166,0.00007064208,0.0001313239,0.0008073287,0.00001395357,0.003087442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001604572,"threshold_uncertainty_score":0.005367875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111551911155081,"score_gpt":0.2634864176284279,"score_spread":0.2323708985168771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}