{"id":"W2170595976","doi":"10.3109/10717544.2014.917442","title":"Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study","year":2014,"lang":"en","type":"article","venue":"Drug Delivery","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"In vivo; Factorial experiment; Mannitol; Gastric fluid; Drug; Pharmacokinetics; Chromatography; Lactose; Dissolution; Stomach; Materials science; Chemistry; Pharmacology; Mathematics; Medicine; Food science; Biochemistry; Organic chemistry; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004331545,0.0002704829,0.0008811445,0.0003734857,0.0000610249,0.00001712885,0.0004075394,0.0001643306,0.00002020702],"category_scores_gemma":[0.0001348517,0.0002240318,0.0001407407,0.000412734,0.0002715574,0.0002806503,0.0001193894,0.0004789642,0.000001509354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007000726,"about_ca_system_score_gemma":0.0001398855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00214482,"about_ca_topic_score_gemma":0.004735698,"domain_scores_codex":[0.9964098,0.001218951,0.001180823,0.0003666831,0.0003310728,0.0004927229],"domain_scores_gemma":[0.9951421,0.003775882,0.0004680519,0.0003544329,0.0001582493,0.0001012965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01346288,0.01900627,0.4422832,0.002905481,0.000710236,0.00008584193,0.1551691,0.006758071,0.3358712,0.001557863,0.01264589,0.009544015],"study_design_scores_gemma":[0.04959607,0.003893518,0.1630799,0.001394474,0.001362071,0.0000397586,0.07357734,0.2595012,0.3977918,0.002528242,0.04478352,0.002452047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962649,0.0004748435,0.00002488749,0.0002906288,0.0005328248,0.001662502,0.0002356023,0.00001201088,0.0005018092],"genre_scores_gemma":[0.9987113,0.0002576058,0.0001725886,0.0006086346,0.00005292832,0.0001095145,0.00001957017,0.00002104722,0.00004674857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2792032,"threshold_uncertainty_score":0.9135752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09639343595035978,"score_gpt":0.379225811416633,"score_spread":0.2828323754662733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}