{"id":"W2170603272","doi":"10.1093/humrep/des395","title":"Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline","year":2012,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Montreal Children's Hospital; Royal Ottawa Mental Health Centre; McGill University; McGill Genome Centre; McGill University Health Centre","funders":"U.S. Public Health Service; De La Salle University; McGill University","keywords":"Biology; DNA methylation; Epigenetics; Haploinsufficiency; Genetics; Germ cell; Reprogramming; Methylation; Andrology; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487608,0.0001740657,0.0002582895,0.0002539663,0.0001135951,0.0002256626,0.0002304318,0.0002859443,0.002212893],"category_scores_gemma":[0.0001653386,0.0002081237,0.0002141771,0.0001254612,0.0002257047,0.0002182604,0.0002110903,0.000665422,0.0004021215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944258,"about_ca_system_score_gemma":0.0001554896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003614067,"about_ca_topic_score_gemma":0.0005376883,"domain_scores_codex":[0.999838,0.00002469802,0.00001664874,0.00005618973,0.00004266292,0.00002170064],"domain_scores_gemma":[0.9996864,0.00005592408,0.0001077816,0.00002754656,0.00002668201,0.00009572654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000247985,0.00006954385,0.003684712,0.00005424263,0.00001729423,0.00006123262,0.00002173966,0.00002203937,0.9936119,0.00006442546,0.00006780006,0.002077046],"study_design_scores_gemma":[0.00008245551,0.002276726,0.0867872,0.00002162113,0.00008680804,0.001196036,0.0001043007,0.0003800046,0.9069425,0.00007451573,0.002039085,0.00000867398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942505,0.001667563,0.002162655,0.0001596032,0.00003126042,0.000051138,0.0008167147,0.0000672329,0.0007933208],"genre_scores_gemma":[0.9908818,0.002115596,0.002196418,0.000193743,0.00003023445,0.0001055265,0.00110051,0.00003785915,0.003338381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212893,"threshold_uncertainty_score":0.007402837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487541073159207,"score_gpt":0.2557681612615385,"score_spread":0.2408927505299464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}