{"id":"W2170603272","doi":"10.1093/humrep/des395","title":"Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline","year":2012,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Montreal Children's Hospital; Royal Ottawa Mental Health Centre; McGill University; McGill Genome Centre; McGill University Health Centre","funders":"U.S. Public Health Service; De La Salle University; McGill University","keywords":"Biology; DNA methylation; Epigenetics; Haploinsufficiency; Genetics; Germ cell; Reprogramming; Methylation; Andrology; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001162321,0.00009428344,0.0001171729,0.0000621315,0.00004438799,0.000003883428,0.0001305428,0.00008858342,0.000003186143],"category_scores_gemma":[0.000124319,0.00006325568,0.00008403454,0.0002384024,0.00006888306,0.000005879848,0.00004739809,0.00008310923,5.601343e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002267837,"about_ca_system_score_gemma":0.00002084135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009105829,"about_ca_topic_score_gemma":0.00006338903,"domain_scores_codex":[0.9987398,0.0002403366,0.0004198307,0.000273799,0.0001763786,0.0001498647],"domain_scores_gemma":[0.9991027,0.000008879533,0.0002464757,0.0005584572,0.00006513803,0.00001830929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006429229,0.0001971182,0.05818845,0.0000288084,0.000004839498,5.667112e-8,0.0003287212,0.001521899,0.9377049,0.000005138272,0.000005936392,0.001949902],"study_design_scores_gemma":[0.0003038373,0.0001241457,0.3294232,0.00001449216,0.000007449486,0.000001029149,0.000009472991,0.00001865914,0.669738,0.00001779684,0.0002965885,0.00004534539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976895,0.001100626,0.00006697413,0.00005860468,0.0004410896,0.0004999753,0.000009096641,0.000002403637,0.0001316966],"genre_scores_gemma":[0.999318,0.00006024834,0.00008595244,0.00000300874,0.0002439407,0.00001715715,0.00001808372,0.00001062552,0.0002430064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2712348,"threshold_uncertainty_score":0.2579492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487541073159207,"score_gpt":0.2557681612615385,"score_spread":0.2408927505299464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}