{"id":"W2170620661","doi":"10.1161/01.res.0000028455.36940.5e","title":"Enhanced Basal Activity of a Cardiac Ca <sup>2+</sup> Release Channel (Ryanodine Receptor) Mutant Associated With Ventricular Tachycardia and Sudden Death","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Mutant; Catecholaminergic polymorphic ventricular tachycardia; HEK 293 cells; Caffeine; Chemistry; Mutation; Internal medicine; Endocrinology; Biology; Cell biology; Biophysics; Endoplasmic reticulum; Biochemistry; Receptor; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008001023,0.000181603,0.000599376,0.000284731,0.0002190355,0.00001854995,0.00005917307,0.0002217056,0.0002190208],"category_scores_gemma":[0.0008164397,0.0001581025,0.0001770914,0.0007825245,0.0002175316,0.0001203037,0.00005417649,0.0005829042,0.00003762607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067977,"about_ca_system_score_gemma":0.000121824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001256361,"about_ca_topic_score_gemma":0.000002372771,"domain_scores_codex":[0.9974284,0.0006150921,0.0002246762,0.0004596606,0.0007444977,0.0005276344],"domain_scores_gemma":[0.9983438,0.0003765597,0.00009501336,0.0003789149,0.0005794995,0.000226165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007488512,0.00321995,0.07226101,0.001213318,0.007252189,0.004057782,0.009431796,0.05330691,0.7993129,0.0005596222,0.01205118,0.02984486],"study_design_scores_gemma":[0.00868096,0.003160137,0.6560837,0.0009073589,0.0007833027,0.000344149,0.0007239629,0.191369,0.135973,0.0003978023,0.0004647394,0.001111891],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967636,0.0008068508,0.0000954589,0.0004201301,0.00003754603,0.0007621317,0.000045952,0.00004177044,0.001026578],"genre_scores_gemma":[0.9989731,0.0002795549,0.00001757611,0.00003292456,0.0002170881,0.00006766441,0.0001032061,0.00003196635,0.0002768629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6633399,"threshold_uncertainty_score":0.6447232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374221846485067,"score_gpt":0.2929459432357393,"score_spread":0.2592037247708887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}