{"id":"W2170620661","doi":"10.1161/01.res.0000028455.36940.5e","title":"Enhanced Basal Activity of a Cardiac Ca <sup>2+</sup> Release Channel (Ryanodine Receptor) Mutant Associated With Ventricular Tachycardia and Sudden Death","year":2002,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Mutant; Catecholaminergic polymorphic ventricular tachycardia; HEK 293 cells; Caffeine; Chemistry; Mutation; Internal medicine; Endocrinology; Biology; Cell biology; Biophysics; Endoplasmic reticulum; Biochemistry; Receptor; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356893,0.0003606851,0.0004061354,0.0001868698,0.00009437375,0.0002348045,0.0002133144,0.0003587983,0.0006341366],"category_scores_gemma":[0.0002079918,0.0001242411,0.0002771103,0.0001450042,0.0001952876,0.0001225509,0.000207802,0.0003333582,0.000280734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232652,"about_ca_system_score_gemma":0.00007506437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001987142,"about_ca_topic_score_gemma":0.0001676977,"domain_scores_codex":[0.9997818,0.0000364189,0.00003674828,0.00005132838,0.00006536611,0.00002848828],"domain_scores_gemma":[0.9998562,0.00002816017,0.00005057127,0.00001789742,0.00001133923,0.00003578521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004571239,0.000008024514,0.0001745959,0.000007202471,0.000003259443,0.00008744433,0.000005545663,0.00001257593,0.9994766,0.00001033791,0.000006567068,0.0001621647],"study_design_scores_gemma":[0.00003317011,0.0006039251,0.02734737,0.000004710053,0.00003247721,0.00350828,0.00003615598,0.002399677,0.9650961,0.00006506692,0.0008586937,0.00001450469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998611,0.0001919512,0.0008353021,0.00002358577,0.00001059784,0.000006440556,0.0001566144,0.00003088464,0.0001336506],"genre_scores_gemma":[0.9973692,0.0001421701,0.001315917,0.00003143798,0.000009577906,0.00002114857,0.000494028,0.00002261341,0.0005938913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006341366,"threshold_uncertainty_score":0.002121389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374221846485067,"score_gpt":0.2929459432357393,"score_spread":0.2592037247708887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}