{"id":"W2170634666","doi":"10.1038/ng.286","title":"DNA methylation profiles in monozygotic and dizygotic twins","year":2009,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":670,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Biology; DNA methylation; Epigenetics; Genetics; Monozygotic twin; CpG site; Buccal swab; Epigenomics; Twin study; Heritability; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002157138,0.000162414,0.0001369123,0.00009381936,0.00004656721,0.00003391762,0.0001213673,0.0004437948,0.000004183188],"category_scores_gemma":[0.0001023929,0.0001606569,0.00003980085,0.0001514427,0.00003448869,0.0000036187,0.0000429672,0.0002208909,0.000002481043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001461012,"about_ca_system_score_gemma":0.00003858498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002190419,"about_ca_topic_score_gemma":0.00002958472,"domain_scores_codex":[0.9989864,0.00005934013,0.0002190108,0.0003549663,0.0001573978,0.0002229221],"domain_scores_gemma":[0.9995133,0.00001378832,0.00006682565,0.0002642426,0.00006738214,0.00007446024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004058494,0.0000810038,0.02608377,0.00001740332,0.00001408819,0.000004100523,0.0001054456,0.0006088162,0.9268485,0.000187523,0.0001168319,0.04589198],"study_design_scores_gemma":[0.0005580211,0.0004022511,0.3685057,0.00001489466,0.00001983033,0.000003500777,0.00002604382,0.0007394672,0.6193364,0.00338279,0.006743161,0.0002678956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793274,0.018392,0.0007413379,0.0002680461,0.0001363384,0.0002414119,0.00000604551,0.00001086657,0.0008765222],"genre_scores_gemma":[0.9944329,0.001640205,0.003191197,0.0002808344,0.0002263487,0.00000556206,0.00007865855,0.00001654737,0.0001277795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3424219,"threshold_uncertainty_score":0.6551397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007357303786291861,"score_gpt":0.2684199468283932,"score_spread":0.2610626430421014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}