{"id":"W2170644025","doi":"10.1016/j.jaac.2014.04.022","title":"Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study","year":2014,"lang":"en","type":"article","venue":"Journal of the American Academy of Child & Adolescent Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; Sunnybrook Hospital; University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre; Centre for Addiction and Mental Health; Hospital for Sick Children; Université de Montréal; Montreal Neurological Institute and Hospital; University of Toronto; Toronto Western Hospital; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research; Pfizer Pharmaceuticals; Seventh Framework Programme; H. Lundbeck A/S; University of British Columbia; Novartis; Ontario Mental Health Foundation; JGW Patterson Foundation; Bundesministerium für Bildung und Forschung; Tuberous Sclerosis Association; GlaxoSmithKline; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Government of Ontario; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Shire; AstraZeneca; Michael Smith Health Research BC; International OCD Foundation; Child and Family Research Institute; Johns Hopkins University; Klingenstein Third Generation Foundation; Roche; Deutsche Forschungsgemeinschaft; Children’s Hospital of Michigan Foundation; Simons Foundation","keywords":"Copy-number variation; Tourette syndrome; Neurodevelopmental disorder; Tic disorder; Etiology; Locus (genetics); Autism; Genome-wide association study; Autism spectrum disorder; Schizophrenia (object-oriented programming); Obsessive compulsive; Genetics; Psychology; Psychiatry; Biology; Genome; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005127488,0.0005542038,0.00047161,0.003025202,0.0009609487,0.0006999149,0.000640995,0.001011393,0.00347567],"category_scores_gemma":[0.001927395,0.0004423485,0.0006138529,0.001630717,0.0007308331,0.000536964,0.0009216149,0.0005286728,0.0004224203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005099924,"about_ca_system_score_gemma":0.000237278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007469175,"about_ca_topic_score_gemma":0.008453022,"domain_scores_codex":[0.999267,0.0001460937,0.0000782327,0.0003254093,0.0000993014,0.00008389014],"domain_scores_gemma":[0.9986009,0.0004044781,0.0003611855,0.0001445338,0.0001962331,0.000292719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007426298,0.0002163239,0.9818724,0.00001943896,0.0004494091,0.002518378,0.001233316,0.00008627178,0.009419324,0.0001159897,0.0001235189,0.003203075],"study_design_scores_gemma":[0.00001719977,0.0001709999,0.996465,0.000005257206,0.00007116409,0.00258786,0.0002376776,0.00008727351,0.0001686557,0.00002371414,0.0001576847,0.000007528912],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994857,0.0001001209,0.00004389928,0.00001209072,0.00000330918,0.00000465249,0.00009585357,0.00000210961,0.0002521636],"genre_scores_gemma":[0.9992703,0.0000743944,0.00005968713,0.00003256061,0.00000712172,0.000006293221,0.0002002141,0.000005681397,0.0003438269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007469175,"threshold_uncertainty_score":0.01485139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006323778082337006,"score_gpt":0.3029559853518974,"score_spread":0.2966322072695604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}