{"id":"W2170668936","doi":"10.1096/fj.02-0397fje","title":"Pseudo‐symmetry of C19‐steroids, alternative binding orientations and multispecificity in human estrogenic 17β‐hydroxysteroid dehydrogenase","year":2002,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Steroid; Dihydrotestosterone; Dehydrogenase; Enzyme kinetics; Enzyme; Chemistry; Hydroxysteroid dehydrogenase; Testosterone (patch); Oxidoreductase; Stereochemistry; Internal medicine; Endocrinology; Biology; Hormone; Biochemistry; Androgen; Active site; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002951762,0.0001540625,0.0001654695,0.0001165502,0.000220453,0.00003548635,0.0002044044,0.0001086094,0.00002629264],"category_scores_gemma":[0.00003428252,0.0001140086,0.0001033295,0.0001462624,0.0001518783,0.00001147199,0.00007843782,0.0003303899,0.000007060751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002636556,"about_ca_system_score_gemma":0.00001423984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002661423,"about_ca_topic_score_gemma":0.00001489768,"domain_scores_codex":[0.9988864,0.0001863518,0.0003294685,0.000192879,0.0001565682,0.0002483039],"domain_scores_gemma":[0.9994129,0.00002956943,0.0002077907,0.0001962213,0.00004300272,0.0001105352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000313068,0.0001001423,0.01048732,0.000007316719,0.0001060307,0.0000348423,0.0003995204,0.0001427517,0.9879332,0.00007787227,0.00009876549,0.0005809736],"study_design_scores_gemma":[0.001457631,0.0003640404,0.0009734823,0.00004623514,0.00004412004,0.000631286,0.0003575318,0.001004489,0.9948435,0.00008277154,0.00004634473,0.000148538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971175,0.002108689,0.0001558479,0.00004782802,0.0001215234,0.000153436,0.00002064752,0.00000443122,0.0002701635],"genre_scores_gemma":[0.9988248,0.0006187862,0.0001892617,0.00003016537,0.0001443581,0.000004876742,0.00001627449,0.00001837043,0.0001531305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00951384,"threshold_uncertainty_score":0.4649136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459336293613018,"score_gpt":0.2520061835756913,"score_spread":0.2374128206395611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}