{"id":"W2170688673","doi":"10.1128/aac.00931-09","title":"Efficacy of Posaconazole against Three Clinical <i>Aspergillus fumigatus</i> Isolates with Mutations in the <i>cyp51A</i> Gene","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Posaconazole; Aspergillus fumigatus; Pharmacodynamics; Pharmacokinetics; Minimum inhibitory concentration; Liter; Biology; Aspergillosis; Area under the curve; Microbiology; Pharmacology; Confidence interval; Medicine; Internal medicine; Antibiotics; Immunology; Amphotericin B; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004624938,0.0005044309,0.0005795289,0.0001645611,0.000143871,0.0003194669,0.0003274207,0.0004499279,0.0005306235],"category_scores_gemma":[0.000444702,0.000165367,0.0003206383,0.000146916,0.0002788595,0.0001974482,0.0001336356,0.0006868031,0.0001820006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004240783,"about_ca_system_score_gemma":0.0002271274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000870523,"about_ca_topic_score_gemma":0.001183718,"domain_scores_codex":[0.9996101,0.0001216355,0.00005225774,0.00006567955,0.00007897542,0.00007123032],"domain_scores_gemma":[0.9996616,0.0001072169,0.00007526736,0.00003578312,0.00004991607,0.00007020562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001910794,0.0007409813,0.001024684,0.00007543506,0.00003909692,0.00009759109,0.00003082644,0.0006796353,0.9911972,0.00004689157,0.0001847556,0.003972045],"study_design_scores_gemma":[0.0004499996,0.04012317,0.01375865,0.00001889474,0.00011015,0.0007667994,0.00004736431,0.003813565,0.9396677,0.0000468877,0.00116946,0.00002740185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984868,0.0004758323,0.0003570007,0.00006457543,0.00002660944,0.00003393947,0.0001383521,0.00002513864,0.0003917645],"genre_scores_gemma":[0.9980389,0.0004141783,0.0007189471,0.00006393639,0.00001770301,0.00002981488,0.0003499523,0.00000735116,0.0003591413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000870523,"threshold_uncertainty_score":0.003076851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907156921422914,"score_gpt":0.2991975082252959,"score_spread":0.2801259390110667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}