{"id":"W2170721683","doi":"10.1002/cbic.200200540","title":"Large‐Scale In Vivo Synthesis of the Carbohydrate Moieties of Gangliosides GM1 and GM2 by Metabolically Engineered <i>Escherichia coli</i>","year":2003,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Institute for Biological Sciences","funders":"","keywords":"Biochemistry; Sialyltransferase; Escherichia coli; Oligosaccharide; Sialic acid; Uridine diphosphate glucose; Uridine diphosphate; Transferase; Galactosyltransferase; Glycosyltransferase; Glycan; Cytidine; Chemistry; Nucleotide salvage; Glycolipid; Biology; Enzyme; Gene; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002494642,0.0001300139,0.0002131292,0.00003657124,0.00002945464,0.00000878389,0.0001676946,0.0001452126,0.00003199031],"category_scores_gemma":[0.0003534424,0.0001049401,0.00007652507,0.0002378587,0.000134966,0.000003357811,0.00007861167,0.00008934977,5.179995e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006656862,"about_ca_system_score_gemma":0.00006350884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002522671,"about_ca_topic_score_gemma":0.00003492298,"domain_scores_codex":[0.9990922,0.00007670802,0.0002357136,0.0002184252,0.000163054,0.000213933],"domain_scores_gemma":[0.9994274,0.0000230139,0.00007594542,0.0003184323,0.00009576565,0.00005946472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003129482,0.00008628877,0.001332233,0.00006268026,0.00002740716,2.227924e-7,0.0001160296,0.000007963144,0.997314,0.00009938279,0.0008869335,0.00003554698],"study_design_scores_gemma":[0.0003940359,0.00002992488,0.0007658858,0.00002020664,0.00001287751,0.000001125149,0.0002163567,0.00004157281,0.9905682,0.00003534489,0.007807532,0.0001069328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954829,0.001866942,0.00004797329,0.0001139426,0.00002693044,0.0001941561,0.00006577936,0.000004115324,0.002197227],"genre_scores_gemma":[0.9986655,0.0001793094,0.0002492449,0.00006906105,0.00001241252,0.00003926691,0.000006096055,0.00001637316,0.0007627402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006920598,"threshold_uncertainty_score":0.4279334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004535406663083223,"score_gpt":0.2115663260903762,"score_spread":0.207030919427293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}