{"id":"W2170743800","doi":"10.1093/molbev/mst241","title":"Earliest Holozoan Expansion of Phosphotyrosine Signaling","year":2013,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Protist diversity and phylogeny","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Broad Institute","keywords":"Biology; Signal transduction; Multicellular organism; Receptor tyrosine kinase; Cell signaling; Genetics; Protein tyrosine phosphatase; Tyrosine; Cell biology; Evolutionary biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008893156,0.00009421253,0.0001059337,0.0000343969,0.00007416169,0.000005521201,0.00008410453,0.0001910658,0.00002825715],"category_scores_gemma":[0.0000339754,0.00009121955,0.0000469205,0.00005444496,0.0001701189,0.000004193325,0.0000954492,0.00005643684,0.00001348168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005988355,"about_ca_system_score_gemma":0.00002182424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547408,"about_ca_topic_score_gemma":0.000003158481,"domain_scores_codex":[0.9994158,0.00006082997,0.000116131,0.0002174183,0.0000386151,0.0001511801],"domain_scores_gemma":[0.9996675,0.000004937776,0.000057066,0.0001516623,0.00007220075,0.00004658491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003255478,0.00001894809,0.04700283,0.00001010952,0.00002418428,7.257023e-7,0.00001513005,0.00001506064,0.9505145,0.001514956,0.0001381172,0.0007129049],"study_design_scores_gemma":[0.0003919542,0.0004056722,0.09803614,0.00001090761,0.00001770961,0.00001136103,0.00004313307,0.00005607242,0.8973801,0.003194746,0.0003063641,0.0001459083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762872,0.002046873,0.02114525,0.00007532878,0.00006772183,0.0001458161,0.00001158882,0.000007684406,0.0002124685],"genre_scores_gemma":[0.9984465,0.00005977637,0.001157168,0.0001236073,0.00003145576,0.00001033745,0.0001025848,0.00000604904,0.00006248264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05313444,"threshold_uncertainty_score":0.3719825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00478013936288815,"score_gpt":0.2167293165781447,"score_spread":0.2119491772152566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}