{"id":"W2170744774","doi":"10.1242/jcs.106963","title":"Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université Laval; Centre hospitalier de l'Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Biology; Stress granule; Poly ADP ribose polymerase; Interactome; DNA damage; Stable isotope labeling by amino acids in cell culture; Biochemistry; Proteomics; Cell biology; DNA; Polymerase; Gene; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009523011,0.0002720602,0.0001409059,0.0002509235,0.0001323546,0.0002106222,0.000167266,0.0003112454,0.0009238129],"category_scores_gemma":[0.00006612487,0.0001285338,0.000159394,0.0002603147,0.0002126697,0.000226432,0.0001409727,0.0005561519,0.000265898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511949,"about_ca_system_score_gemma":0.0001119212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005624898,"about_ca_topic_score_gemma":0.0007224235,"domain_scores_codex":[0.9998986,0.000009150446,0.000005175088,0.00003970984,0.0000264606,0.00002100047],"domain_scores_gemma":[0.9999522,0.000008767482,0.00001452535,0.000005141147,0.000007420839,0.00001199994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003602843,0.000006063,0.00007975103,0.00001464941,0.000002438046,0.00001524516,0.000008963181,0.00002083134,0.9990133,0.00004627165,0.00002486631,0.0007315564],"study_design_scores_gemma":[0.000005990743,0.00005543653,0.01019635,0.000002996827,0.000009065139,0.0001360838,0.00002438197,0.001645457,0.9866622,0.0001060711,0.001150575,0.000005335437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477431,0.002371076,0.04540607,0.0003397356,0.00004920287,0.00004773001,0.001338676,0.0003920934,0.002312198],"genre_scores_gemma":[0.9718784,0.001373623,0.02156691,0.0002000822,0.00001597586,0.0001058596,0.000851404,0.00005674049,0.003950981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009238129,"threshold_uncertainty_score":0.003090441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02667794860115665,"score_gpt":0.3313415733862197,"score_spread":0.304663624785063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}