{"id":"W2170796380","doi":"10.1093/gerona/glu241","title":"Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs","year":2015,"lang":"en","type":"article","venue":"The Journals of Gerontology Series A","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Senescence; Extracellular matrix; PI3K/AKT/mTOR pathway; Cell biology; Mechanistic target of rapamycin; Myofibroblast; Biology; Lung; Extracellular; Cancer research; Signal transduction; Endocrinology; Chemistry; Internal medicine; Medicine; Fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002419579,0.0002134172,0.0001734661,0.0003032491,0.0001065981,0.0002374697,0.00008589427,0.0001480369,0.001075547],"category_scores_gemma":[0.0001544726,0.0001025116,0.0001487866,0.0001064661,0.0001816092,0.0001819302,0.0002051471,0.0002634291,0.0002494236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008384559,"about_ca_system_score_gemma":0.0001106868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001627139,"about_ca_topic_score_gemma":0.0003326179,"domain_scores_codex":[0.9999443,0.00001306884,0.000005443126,0.000009238799,0.00001643526,0.00001145733],"domain_scores_gemma":[0.9998734,0.00001239222,0.0000501761,0.00001238004,0.00002031796,0.0000313407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000200745,0.00003556376,0.009131048,0.00007072556,0.00001701408,0.0003310656,0.00009175115,0.00005105371,0.9803227,0.0002601016,0.0001492665,0.009338753],"study_design_scores_gemma":[0.00003349843,0.001934218,0.5400857,0.00006608438,0.0001274259,0.005487856,0.0003836929,0.001126806,0.4320925,0.001616689,0.01702289,0.00002244265],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786714,0.01720627,0.002347682,0.0001510681,0.00004799692,0.00002268609,0.0001624571,0.00004756063,0.0013429],"genre_scores_gemma":[0.9916804,0.005433198,0.0009037747,0.00006874974,0.00005158108,0.00001355537,0.0001225506,0.000005515035,0.001720692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075547,"threshold_uncertainty_score":0.003598034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.117148903339457,"score_gpt":0.3403288677178964,"score_spread":0.2231799643784394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}