{"id":"W2170797456","doi":"10.1128/aac.01617-08","title":"Inactivation of the Glycoside Hydrolase NagZ Attenuates Antipseudomonal β-Lactam Resistance in <i>Pseudomonas aeruginosa</i>","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pseudomonas aeruginosa; Microbiology; Biology; Peptidoglycan; Aztreonam; Antibiotics; Cephalosporin; Antibiotic resistance; Enzyme; Bacteria; Biochemistry; Genetics; Imipenem","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009884714,0.0004529227,0.000320794,0.0001622018,0.00008822339,0.0002976098,0.0003008408,0.0002648518,0.0009235417],"category_scores_gemma":[0.0001326309,0.0001411845,0.0002824969,0.0001120692,0.0002644874,0.0001583147,0.0002664555,0.0006864824,0.0002736945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002445833,"about_ca_system_score_gemma":0.0002015822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318631,"about_ca_topic_score_gemma":0.001112404,"domain_scores_codex":[0.9998216,0.00002069874,0.00001861701,0.00002537529,0.00006508407,0.00004869372],"domain_scores_gemma":[0.9998517,0.00002439076,0.00005435616,0.00001639964,0.00001419031,0.00003890421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003972578,0.00003014553,0.000115816,0.000009760693,0.000002704332,0.00002485314,0.000008649623,0.00002449166,0.9992568,0.00002455898,0.00001064675,0.000451865],"study_design_scores_gemma":[0.000009961486,0.0003512989,0.005976554,0.000004254374,0.00001320814,0.0001411069,0.00003893335,0.0007632509,0.9917814,0.00002068031,0.0008944275,0.000004953409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980152,0.0002988669,0.0008622558,0.00007239873,0.00001069027,0.00001579277,0.0001762422,0.00005617616,0.000492278],"genre_scores_gemma":[0.9966187,0.0002694887,0.0009738309,0.00005399811,0.000006936011,0.00002231681,0.0003747754,0.00002910833,0.001650761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318631,"threshold_uncertainty_score":0.003089547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005647260662951356,"score_gpt":0.2251153324721981,"score_spread":0.2194680718092468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}