{"id":"W2170802261","doi":"10.1093/database/bar021","title":"A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway","year":2011,"lang":"en","type":"article","venue":"Database","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"The Wellcome Trust DBT India Alliance; Council of Scientific and Industrial Research, India; Department of Biotechnology, Ministry of Science and Technology, India; Wellcome Trust","keywords":"RANKL; RANK Ligand; Osteoclast; NFAT; Activator (genetics); Cell biology; Biology; Signal transduction; Cancer research; PI3K/AKT/mTOR pathway; Transcription factor; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007197999,0.0001164806,0.0001351665,0.00003602512,0.00003698732,0.000005232492,0.0001196617,0.00005815671,0.00008877012],"category_scores_gemma":[0.00002943641,0.0001088864,0.00006730233,0.00005164165,0.00006164423,0.000009701441,0.00008710247,0.00004775623,0.0000336401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002127714,"about_ca_system_score_gemma":0.00005041573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631799,"about_ca_topic_score_gemma":0.00001029358,"domain_scores_codex":[0.9992734,0.00006043244,0.0001883665,0.0002374296,0.00009668111,0.0001437115],"domain_scores_gemma":[0.9993054,0.000007576399,0.00009541407,0.0003901049,0.0001209877,0.00008056605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003727911,0.0001421621,0.0003467313,0.00006012285,0.0000378875,0.0000138401,0.00005110962,0.000001110684,0.9952389,0.0001657189,0.002649459,0.000920145],"study_design_scores_gemma":[0.000826792,0.00008127477,0.003196866,0.00002238149,0.00005108307,0.000007915282,0.0001646374,0.000009333611,0.9512604,0.0000478968,0.04416977,0.0001616004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950188,0.00192094,0.0009969434,0.00001170568,0.0001748741,0.0001368083,0.001147148,0.00001646143,0.0005762705],"genre_scores_gemma":[0.9951239,0.0000951902,0.001301443,0.0001625258,0.0001036523,0.00001118816,0.003059879,0.00001507409,0.0001271039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04397847,"threshold_uncertainty_score":0.4440258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03295461600734513,"score_gpt":0.2515163771703015,"score_spread":0.2185617611629564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}