{"id":"W2170803020","doi":"10.1016/j.jmb.2005.07.027","title":"Structural Snapshots of MTA/AdoHcy Nucleosidase Along the Reaction Coordinate Provide Insights into Enzyme and Nucleoside Flexibility During Catalysis","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Chemistry; Stereochemistry; Active site; Hydrolase; Nucleoside; Substrate (aquarium); Substrate analog; Enzyme; Purine; Catalytic cycle; Product inhibition; Enzyme catalysis; Biochemistry; Biology; Non-competitive inhibition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118439,0.0003797023,0.0003253577,0.0002029589,0.0008124874,0.0008540168,0.0004681123,0.0005892083,0.003200038],"category_scores_gemma":[0.0002689419,0.0003818455,0.0002591778,0.0003449303,0.0003409654,0.000650239,0.0002334165,0.001713069,0.0003104625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000975469,"about_ca_system_score_gemma":0.0009158471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006552692,"about_ca_topic_score_gemma":0.00721509,"domain_scores_codex":[0.99994,0.000005921767,0.000002042842,0.00000844304,0.00001951013,0.00002405664],"domain_scores_gemma":[0.9998496,0.00004704698,0.00002113001,0.00001388421,0.00001704681,0.00005139122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00429712,0.000854907,0.01071734,0.0005217416,0.0001672825,0.004009011,0.001735656,0.1234301,0.7809198,0.0330066,0.007798896,0.03254155],"study_design_scores_gemma":[0.0004030469,0.0008928778,0.02787917,0.0001288833,0.0001498611,0.001080453,0.00169182,0.3988975,0.5322961,0.012829,0.02351046,0.0002408743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851016,0.000623243,0.00611503,0.0005987668,0.00004811423,0.00001807429,0.0007113533,0.000348695,0.006435066],"genre_scores_gemma":[0.9932292,0.0005111245,0.004410763,0.00004169701,0.000007201228,0.00001451301,0.0006435648,0.00004722368,0.001094774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006552692,"threshold_uncertainty_score":0.0130291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008926517679673198,"score_gpt":0.2815918555985469,"score_spread":0.2726653379188737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}