{"id":"W2170831380","doi":"10.1126/science.1182213","title":"Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a <i>Pitx1</i> Enhancer","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1063,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Enhancer; Genetics; Homeobox; Phenotype; Gene; Locus (genetics); Allele; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656924,0.0002150013,0.0001291912,0.0003063806,0.0001731993,0.0001923458,0.0002587723,0.0003433971,0.000656431],"category_scores_gemma":[0.0002132793,0.0001534932,0.0001452578,0.0001112774,0.0004231502,0.0001367395,0.0004041801,0.0004575874,0.000149531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237839,"about_ca_system_score_gemma":0.0001586426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005489065,"about_ca_topic_score_gemma":0.0009064763,"domain_scores_codex":[0.9999188,0.00001156073,0.00000669244,0.00002639239,0.00001863929,0.00001796728],"domain_scores_gemma":[0.9998691,0.00002174368,0.00005179402,0.00002146785,0.000008700729,0.0000270628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007596245,0.00001409053,0.006968028,0.00001557585,0.000009218455,0.0003337229,0.00006312228,0.0001683794,0.9890192,0.0001925463,0.00002324306,0.00311684],"study_design_scores_gemma":[0.00007297948,0.001159781,0.6773332,0.00002446323,0.00007821607,0.01030062,0.0002962024,0.003624559,0.3027568,0.0007283122,0.003564215,0.0000606647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989412,0.00008278559,0.0004988331,0.00002054817,0.000002008037,0.000004836904,0.00003098342,0.00002376908,0.0003949668],"genre_scores_gemma":[0.9985653,0.00008861658,0.0005756448,0.00003753178,0.000004542552,0.000009131972,0.000117154,0.00001417163,0.0005881056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000656431,"threshold_uncertainty_score":0.002195954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006731267177317968,"score_gpt":0.2621134080151713,"score_spread":0.2553821408378533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}