{"id":"W2170831380","doi":"10.1126/science.1182213","title":"Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a <i>Pitx1</i> Enhancer","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1063,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Enhancer; Genetics; Homeobox; Phenotype; Gene; Locus (genetics); Allele; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002048015,0.00005456588,0.00008203318,0.00004350956,0.00002687209,0.000003999759,0.0001243839,0.00004377666,0.00001085965],"category_scores_gemma":[0.00005576447,0.00005044626,0.00002949578,0.0001985842,0.0002867046,0.000009004251,0.00002134757,0.00003728522,0.000001229875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002241345,"about_ca_system_score_gemma":0.00009364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001131616,"about_ca_topic_score_gemma":0.000006091365,"domain_scores_codex":[0.9992931,0.00001998702,0.0002139873,0.0001871358,0.0001714832,0.0001142448],"domain_scores_gemma":[0.9996142,0.00000399072,0.0001051166,0.0001079714,0.000140044,0.00002870962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005993523,0.0001159286,0.0001890614,0.00000580721,0.000001151326,8.451562e-8,0.00007150913,0.0000323759,0.9841412,0.0002777974,0.000104094,0.01500102],"study_design_scores_gemma":[0.0002809849,0.001275692,0.01964781,0.00003781143,0.000004308663,0.000003124794,0.0005656249,0.0001879047,0.9764707,0.001148759,0.0002911661,0.00008613481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969603,0.0007134612,0.001043047,0.00007765314,0.00008817996,0.00007215067,0.000006069362,0.000002226111,0.001036854],"genre_scores_gemma":[0.9993529,0.0001385109,0.000294637,0.00002252421,0.00002518986,0.000002510112,0.000005407115,0.000001448051,0.0001569015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01945875,"threshold_uncertainty_score":0.2057139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006731267177317968,"score_gpt":0.2621134080151713,"score_spread":0.2553821408378533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}