{"id":"W2170833449","doi":"10.1042/bse0560149","title":"Many roads lead to Rome? Multiple modes of Cu,Zn superoxide dismutase destabilization, misfolding and aggregation in amyotrophic lateral sclerosis","year":2014,"lang":"en","type":"article","venue":"Essays in Biochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Amyotrophic lateral sclerosis; Proteostasis; Protein aggregation; Superoxide dismutase; Amyloid (mycology); Protein folding; Autophagy; Neuroscience; Biology; Disease; Neurodegeneration; Cell biology; Oxidative stress; Medicine; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004404152,0.0002112007,0.0003811134,0.0001983755,0.00004584224,0.00003005849,0.000155497,0.0001816802,0.00003707213],"category_scores_gemma":[0.0007415299,0.0002009372,0.00004916455,0.0004927599,0.0001568366,0.0001253186,0.0001393693,0.0002542417,0.000005061653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002057746,"about_ca_system_score_gemma":0.00005027645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444307,"about_ca_topic_score_gemma":0.00006205419,"domain_scores_codex":[0.9981611,0.00008251001,0.0004933086,0.0004910058,0.0003787358,0.0003933227],"domain_scores_gemma":[0.9991245,0.0001102222,0.00007421785,0.0003885564,0.0001096508,0.0001928375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001068715,0.00009261209,0.4116257,0.0001231134,0.000006298982,0.000003489541,0.0001554016,0.0002507769,0.5859457,0.00001572991,0.00003410238,0.001640257],"study_design_scores_gemma":[0.001833448,0.0000859083,0.5025658,0.0008283143,0.00001058067,0.000009394331,0.00006012955,0.01184575,0.4824443,0.0001170692,0.00000935873,0.0001899297],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982523,0.0002245691,0.0002313086,0.0007700367,0.00002089314,0.0003562325,0.00001520391,0.00003001531,0.00009944343],"genre_scores_gemma":[0.9977004,0.0002208605,0.00165063,0.0001272385,0.00005388518,0.00005702573,0.00006848836,0.00003446374,0.00008701653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1035014,"threshold_uncertainty_score":0.8193982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02257424013660981,"score_gpt":0.2685078165308813,"score_spread":0.2459335763942715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}