{"id":"W2170833925","doi":"10.1126/scisignal.2005802","title":"How to Become a Control FreakReview and commentary on <i>Signal Transduction: Principles, Pathways, and Processes</i> , edited by Lewis C. Cantley, Tony Hunter, Richard Sever,and Jeremy Thorner. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2014. 452 pp. ISBN: 978-0-879699-01-7","year":2014,"lang":"en","type":"article","venue":"Science Signaling","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Budding; Spring (device); Signal transduction; Environmental ethics; Biology; Philosophy; Cell biology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001604605,0.0004558935,0.00051053,0.00008217914,0.0005128153,0.0003998588,0.0005010694,0.0001620769,0.000007863465],"category_scores_gemma":[0.0002239317,0.0004335083,0.0000568958,0.0003688209,0.0003873177,0.0001114756,0.0003034478,0.0003208581,0.000002192386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006663717,"about_ca_system_score_gemma":0.0002095316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449002,"about_ca_topic_score_gemma":0.00003557393,"domain_scores_codex":[0.9969561,0.0001745798,0.0004329606,0.001224407,0.0005272962,0.000684717],"domain_scores_gemma":[0.9984293,0.00009614204,0.0002462472,0.0004660097,0.0002829071,0.0004793784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005625114,0.0001009424,0.003317407,0.0002562146,0.000058085,0.000001249612,0.00006159241,0.0000444531,0.991686,0.0001556053,0.004013076,0.0002490789],"study_design_scores_gemma":[0.001391116,0.0004421019,0.0002891604,0.0002893322,0.00007866942,0.000002676773,0.00004060011,0.0003628887,0.7307566,0.000001548933,0.2657959,0.0005493672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9077396,0.06773989,0.01407512,0.007083724,0.000681342,0.00222227,0.0002948601,0.0001103053,0.00005286223],"genre_scores_gemma":[0.9907187,0.003977181,0.001467242,0.002985518,0.0006365206,0.0001238631,0.000004656566,0.00005026426,0.000036026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2617829,"threshold_uncertainty_score":0.9998116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001216122312133,"score_gpt":0.2226041409906823,"score_spread":0.2125919797675609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}