{"id":"W2170956038","doi":"10.1074/jbc.m110.203679","title":"Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Ottawa Hospital; University of Ottawa","funders":"Shanghai Jiao Tong University; University of Ottawa; State University of New York; SUNY Downstate Medical Center; Heart and Stroke Foundation of Canada","keywords":"Very low-density lipoprotein; Apolipoprotein B; Microsomal triglyceride transfer protein; Lipid droplet; Biochemistry; Secretion; Lipid metabolism; Biology; Mutant; Lipoprotein; Chemistry; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671412,0.000161727,0.0004667351,0.00006321708,0.00004023754,0.000008762319,0.0001965237,0.0003281641,0.000005901689],"category_scores_gemma":[0.0005815531,0.0001000065,0.0001299835,0.0001400562,0.0001872356,0.00001118536,0.00007656212,0.0002235365,1.559595e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001859454,"about_ca_system_score_gemma":0.00007429316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003012176,"about_ca_topic_score_gemma":0.00002026396,"domain_scores_codex":[0.9982997,0.0001952698,0.0009641225,0.0002144946,0.0001600408,0.000166418],"domain_scores_gemma":[0.9986191,0.00006896588,0.0009460124,0.0001813488,0.0001177573,0.00006679105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002969753,0.0002116053,0.00557313,0.00006338744,0.00003355072,0.00004019365,0.0003720634,0.000002490053,0.9902126,0.000003016888,0.000007794158,0.0005103954],"study_design_scores_gemma":[0.002082352,0.0003827174,0.028449,0.0001268805,0.00002366668,0.0002155658,0.00063741,0.000007413737,0.9678789,0.00007235556,0.000009943073,0.0001138282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994654,0.0002011009,0.00001840732,0.00002665426,0.0000586411,0.0001271953,0.00001047981,0.000002099814,0.00009002925],"genre_scores_gemma":[0.9991807,0.00008620236,0.0004744378,0.0000135089,0.0002023059,0.000002979222,0.00002039019,0.000006430664,0.00001304409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02287587,"threshold_uncertainty_score":0.4078148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330482254105639,"score_gpt":0.2467058285375114,"score_spread":0.223401005996455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}