{"id":"W2170956038","doi":"10.1074/jbc.m110.203679","title":"Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Ottawa Hospital; University of Ottawa","funders":"Shanghai Jiao Tong University; University of Ottawa; State University of New York; SUNY Downstate Medical Center; Heart and Stroke Foundation of Canada","keywords":"Very low-density lipoprotein; Apolipoprotein B; Microsomal triglyceride transfer protein; Lipid droplet; Biochemistry; Secretion; Lipid metabolism; Biology; Mutant; Lipoprotein; Chemistry; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883797,0.0006492804,0.0003217164,0.0002416937,0.0002394135,0.0002993354,0.0003166672,0.0007194747,0.001361089],"category_scores_gemma":[0.0003239849,0.0002735328,0.0005408538,0.0002799995,0.0006543336,0.0001010106,0.0002464111,0.0006893054,0.0009584872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005407968,"about_ca_system_score_gemma":0.0003479531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347135,"about_ca_topic_score_gemma":0.001363392,"domain_scores_codex":[0.9997879,0.00003455194,0.00003977279,0.00004269012,0.00005792803,0.00003719758],"domain_scores_gemma":[0.999718,0.00007364422,0.00006918044,0.00003820824,0.00001626705,0.00008483394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005730388,0.0001238011,0.001003393,0.00003568858,0.00003763113,0.002669896,0.00003921786,0.0001607816,0.9937361,0.0001538195,0.0001301127,0.001336439],"study_design_scores_gemma":[0.0003967387,0.001342495,0.04933464,0.00004739638,0.0001872633,0.02748947,0.0001498688,0.005985296,0.9096336,0.0003053116,0.005048988,0.0000787853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972466,0.0001573247,0.001425927,0.00007805456,0.0000448001,0.00003613038,0.0004397188,0.00007773202,0.0004937319],"genre_scores_gemma":[0.9971898,0.0001292689,0.00101418,0.0000904605,0.00001614312,0.00002525909,0.0005172459,0.00005825315,0.0009593268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347135,"threshold_uncertainty_score":0.004666924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330482254105639,"score_gpt":0.2467058285375114,"score_spread":0.223401005996455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}