{"id":"W2170978231","doi":"10.2165/00003495-200262060-00007","title":"Tamoxifen Resistant and Refractory Breast Cancer","year":2002,"lang":"en","type":"review","venue":"Drugs","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Tamoxifen; Medicine; Aromatase; Breast cancer; Exemestane; Aminoglutethimide; Anastrozole; Letrozole; Internal medicine; Oncology; Aromatase inhibitor; Antiestrogen; Adjuvant therapy; Megestrol acetate; Cancer; Hormonal therapy; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000089847,0.0003092214,0.0005448508,0.00004961989,0.00006590672,0.00002393176,0.0001541314,0.000582698,0.00004593592],"category_scores_gemma":[0.000008706971,0.0002333899,0.0002167922,0.00008038402,0.00007668461,0.00000168472,0.0001090438,0.0002788674,0.00003985993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002947939,"about_ca_system_score_gemma":0.00009977586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002301605,"about_ca_topic_score_gemma":0.000002203541,"domain_scores_codex":[0.998898,0.0001000687,0.00022976,0.0004325243,0.0001013898,0.0002382083],"domain_scores_gemma":[0.999351,0.00001458004,0.0001482945,0.0003392905,0.0000269524,0.0001199306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001607466,0.00003283754,0.000002373608,0.00198182,0.0002529857,0.00001625885,0.00002309014,7.362153e-8,0.0003211173,0.00001342138,0.01083107,0.9865088],"study_design_scores_gemma":[0.000142089,0.00005645046,0.00000466738,0.001627265,0.000313831,0.00008376854,0.000004215366,6.126845e-7,0.00003617004,0.000002374468,0.9974378,0.0002907358],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003132994,0.9968963,5.467637e-7,0.00002637367,0.0001610622,0.0002499147,0.0001313364,0.00001453971,0.002206689],"genre_scores_gemma":[0.0001737981,0.9953003,0.00001737153,0.00004468223,0.0004074012,0.000059728,0.0001749242,0.00005989775,0.003761888],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9866068,"threshold_uncertainty_score":0.9517366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170429138392817,"score_gpt":0.282447185699758,"score_spread":0.2707428943158298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}