{"id":"W2170978231","doi":"10.2165/00003495-200262060-00007","title":"Tamoxifen Resistant and Refractory Breast Cancer","year":2002,"lang":"en","type":"review","venue":"Drugs","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Tamoxifen; Medicine; Aromatase; Breast cancer; Exemestane; Aminoglutethimide; Anastrozole; Letrozole; Internal medicine; Oncology; Aromatase inhibitor; Antiestrogen; Adjuvant therapy; Megestrol acetate; Cancer; Hormonal therapy; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005265306,0.001144093,0.002069244,0.00205203,0.0003385607,0.0009899221,0.0013254,0.001323902,0.002616217],"category_scores_gemma":[0.0008088119,0.0002785877,0.0003135776,0.002434119,0.0005798775,0.001184039,0.00043952,0.001747389,0.002237589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007049375,"about_ca_system_score_gemma":0.0006785587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001163312,"about_ca_topic_score_gemma":0.003554034,"domain_scores_codex":[0.9998492,0.00002827019,0.00002112843,0.00002658077,0.00005901208,0.00001577222],"domain_scores_gemma":[0.9997528,0.0001071725,0.00003351666,0.0000101184,0.0000710684,0.00002539068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001220132,0.0000760159,0.0001390931,0.006993987,0.00005544887,0.0004926585,0.00002940534,0.0003491568,0.001670746,0.002414208,0.06548091,0.9221764],"study_design_scores_gemma":[0.0000304692,0.00005319175,0.0004281188,0.001027964,0.0000922479,0.002030682,0.00003331634,0.00008639689,0.0003383147,0.001078266,0.9947903,0.00001073257],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001039155,0.9976421,0.0002397801,0.0002835241,0.0005550643,0.000005209692,0.00001612606,0.000009226252,0.001144932],"genre_scores_gemma":[0.0006850932,0.9962826,0.0003288141,0.0004247492,0.0004909463,0.000009781644,0.00003906316,0.000002109011,0.001736891],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002616217,"threshold_uncertainty_score":0.008752167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01170429138392817,"score_gpt":0.282447185699758,"score_spread":0.2707428943158298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}