{"id":"W2170989849","doi":"10.1101/cshperspect.a009522","title":"Dynamics Intrinsic to Cystic Fibrosis Transmembrane Conductance Regulator Function and Stability","year":2013,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of General Medical Sciences; Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis transmembrane conductance regulator; Gating; Biophysics; Folding (DSP implementation); Cyclic nucleotide-binding domain; Cystic fibrosis; Chemistry; Transmembrane domain; Mutation; Function (biology); Cell biology; Nucleotide; Biology; Biochemistry; Genetics; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000561798,0.0008730794,0.001475701,0.001703456,0.0004327453,0.001206783,0.0009577966,0.001246814,0.003738504],"category_scores_gemma":[0.000789296,0.0003813672,0.0004017138,0.001632594,0.0008671316,0.00176092,0.0009985403,0.001649348,0.003797828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001096492,"about_ca_system_score_gemma":0.0009585844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318081,"about_ca_topic_score_gemma":0.001524674,"domain_scores_codex":[0.9998052,0.00002773209,0.00001947939,0.00003751744,0.00008429421,0.00002587796],"domain_scores_gemma":[0.9997788,0.00006398522,0.00003200272,0.000009562922,0.00008466404,0.00003093049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001092643,0.00005768474,0.0002421186,0.01126229,0.00006749176,0.0002480714,0.0001045329,0.0005067901,0.005229949,0.01189982,0.03949903,0.930773],"study_design_scores_gemma":[0.0000106338,0.00004747318,0.0005028603,0.001095378,0.00003252513,0.0005984741,0.00003582127,0.00009202697,0.000808502,0.003256402,0.9935024,0.00001745869],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001625338,0.9970331,0.0001343076,0.0002766353,0.0001921109,0.000003959802,0.00001658777,0.000008702544,0.002172083],"genre_scores_gemma":[0.001230281,0.9972602,0.000137257,0.0001411193,0.0001832624,0.000007512197,0.00002877345,0.000001963046,0.001009574],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003738504,"threshold_uncertainty_score":0.01250648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03826816293575759,"score_gpt":0.3360471836975822,"score_spread":0.2977790207618246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}