{"id":"W2171057168","doi":"10.1016/s0968-0896(00)00083-3","title":"Controlled site-selective protein glycosylation for precise glycan structure–catalytic activity relationships","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Glycan; Glycosylation; Stereochemistry; Anomer; Biochemistry; Active site; Glycoprotein; Combinatorial chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007491215,0.0005273168,0.0004514189,0.0002311049,0.0001855416,0.0007282978,0.0005944125,0.0003837095,0.000949091],"category_scores_gemma":[0.0004231359,0.0003189165,0.0002257753,0.0003541118,0.0004136959,0.0005582098,0.000553005,0.001086118,0.0003795654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000520786,"about_ca_system_score_gemma":0.0002642905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002266778,"about_ca_topic_score_gemma":0.0005501943,"domain_scores_codex":[0.9997059,0.00005437742,0.00003220865,0.00007157191,0.00008110855,0.00005489597],"domain_scores_gemma":[0.9997821,0.00006891752,0.00005373534,0.00005207727,0.00001819894,0.00002494302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000137988,0.00006752957,0.00009101554,0.00003313795,0.000007894671,0.00003413074,0.00002241642,0.0003124424,0.990118,0.002090901,0.0001624636,0.006922183],"study_design_scores_gemma":[0.0000206217,0.0000807675,0.000165865,0.000002087043,0.000006764508,0.00007874092,0.000003692521,0.000996127,0.9966763,0.0002250749,0.001737343,0.000006486278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8973567,0.003405225,0.08988529,0.0004705423,0.0002109545,0.0002455639,0.0005402424,0.0007228857,0.007162597],"genre_scores_gemma":[0.9779125,0.001059065,0.01844879,0.0001327463,0.00002853396,0.00006324417,0.0003042502,0.00007931635,0.001971554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000949091,"threshold_uncertainty_score":0.003961802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455039941549395,"score_gpt":0.263359627878745,"score_spread":0.2488092284632511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}