{"id":"W2171062007","doi":"10.1016/j.cell.2011.05.039","title":"An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; Structural Genomics Consortium; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Argonne National Laboratory; National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy","keywords":"Biology; Allosteric regulation; Ubiquitin; Enzyme; Ubiquitin-conjugating enzyme; Biochemistry; Ubiquitins; Ubiquitin-Protein Ligases; Genetics; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930079,0.0004320329,0.0003268363,0.0002618458,0.0002561053,0.0003145798,0.0004493868,0.0002440459,0.002609821],"category_scores_gemma":[0.0002142805,0.0001448738,0.0001472206,0.0002656471,0.0002220957,0.0001138205,0.0001892105,0.0005945973,0.0004521292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005367973,"about_ca_system_score_gemma":0.0004489548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113245,"about_ca_topic_score_gemma":0.002322339,"domain_scores_codex":[0.999879,0.00001965741,0.000009017998,0.00002282075,0.00003555155,0.00003394216],"domain_scores_gemma":[0.9999301,0.00002135805,0.00001020224,0.00001172218,0.000006452577,0.00002013651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009189557,0.0002814865,0.0002359443,0.000131399,0.00002603391,0.000145079,0.00001959364,0.0005823925,0.9849949,0.001590264,0.0008982727,0.0101756],"study_design_scores_gemma":[0.0001598917,0.0004355688,0.0007495351,0.000009429821,0.00003235798,0.000286193,0.00001099471,0.001903192,0.9860901,0.000135024,0.01017886,0.000008873726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594799,0.01396539,0.01047593,0.0005296929,0.0004657014,0.0001658737,0.0006495896,0.0007736287,0.0134942],"genre_scores_gemma":[0.9889917,0.002936473,0.00301807,0.0001092438,0.00003739628,0.0000491941,0.0004919731,0.00002679776,0.004339187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002609821,"threshold_uncertainty_score":0.00873071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02405926247672811,"score_gpt":0.2397199299285958,"score_spread":0.2156606674518677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}