{"id":"W2171062007","doi":"10.1016/j.cell.2011.05.039","title":"An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme","year":2011,"lang":"en","type":"article","venue":"Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":234,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; Structural Genomics Consortium; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Argonne National Laboratory; National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy","keywords":"Biology; Allosteric regulation; Ubiquitin; Enzyme; Ubiquitin-conjugating enzyme; Biochemistry; Ubiquitins; Ubiquitin-Protein Ligases; Genetics; Ubiquitin ligase; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416241,0.0001041336,0.00009055621,0.00001375149,0.00008253475,0.000008111945,0.0002892196,0.00009732629,0.0001442366],"category_scores_gemma":[0.00001289046,0.00008030324,0.00007654589,0.00004578826,0.00008179418,0.000003004932,0.000124398,0.00007411151,0.00001128807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003748692,"about_ca_system_score_gemma":0.00002955932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000252014,"about_ca_topic_score_gemma":0.00001366037,"domain_scores_codex":[0.999308,0.00007506925,0.000171853,0.0001993665,0.0000772247,0.0001684384],"domain_scores_gemma":[0.9993609,0.000003538515,0.0001144964,0.0004205894,0.00004622113,0.0000542483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009747754,0.00006605712,0.001322747,0.00002799901,0.000005416787,7.187289e-7,0.0004000229,5.700447e-7,0.997573,0.00006452501,0.0002586863,0.0002705329],"study_design_scores_gemma":[0.000219858,0.0002689351,0.001451394,0.00001367078,0.000008398246,0.000003264379,0.0001386893,0.000004999426,0.9946349,0.0001130891,0.003033727,0.0001090456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677207,0.0001579434,0.00004209403,0.000008201137,0.0001154983,0.0001473984,0.0000121384,0.000009533211,0.03178651],"genre_scores_gemma":[0.9984085,0.000005280876,0.0004222767,0.0001870592,0.0002108634,0.00001203831,0.00002310789,0.00001895711,0.000711897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03107461,"threshold_uncertainty_score":0.3274671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02405926247672811,"score_gpt":0.2397199299285958,"score_spread":0.2156606674518677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}