{"id":"W2171093150","doi":"10.1124/mol.109.061804","title":"Functional Characterization of Vasopressin Type 2 Receptor Substitutions (R137H/C/L) Leading to Nephrogenic Diabetes Insipidus and Nephrogenic Syndrome of Inappropriate Antidiuresis: Implications for Treatments","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health; Kidney Foundation of Canada","keywords":"Nephrogenic diabetes insipidus; Vasopressin; Endocrinology; Endocytosis; Internal medicine; Internalization; Vasopressin receptor; Arginine vasopressin receptor 2; Chemistry; Receptor; Biology; Medicine; Antagonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009160316,0.0001341615,0.0001876114,0.0001061248,0.00008626904,0.000005699101,0.00009273348,0.0001618559,0.00002841967],"category_scores_gemma":[0.00001795269,0.000141243,0.00008355262,0.0001752024,0.0001030359,0.00001006213,0.00003184852,0.00005793638,0.000002368348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009068922,"about_ca_system_score_gemma":0.00007862316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000024646,"about_ca_topic_score_gemma":0.000003208112,"domain_scores_codex":[0.9991971,0.00003403934,0.0002581542,0.0002679497,0.00006180196,0.0001809578],"domain_scores_gemma":[0.9993999,0.00001013541,0.00013791,0.0001630649,0.000214883,0.00007408757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001119692,0.0001151905,0.005180788,0.00003712781,0.0002272539,2.905814e-7,0.00002580512,0.00005815744,0.9933295,0.0003186036,0.00009575419,0.0004995721],"study_design_scores_gemma":[0.0007259568,0.0002666393,0.06676039,0.000006756306,0.0001822305,0.000008389798,0.000004671886,0.00003082323,0.929615,0.00006912547,0.002212254,0.0001177931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942974,0.0001678702,0.004186493,0.0002724434,0.0003794911,0.0005423318,0.0001335978,0.0000107195,0.000009684114],"genre_scores_gemma":[0.9975629,0.00005962953,0.0007268347,0.0001476363,0.00008119478,0.0001534418,0.001184632,0.00002153518,0.00006221366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06371452,"threshold_uncertainty_score":0.5759721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173712280695287,"score_gpt":0.2610137286777995,"score_spread":0.2492766058708466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}