{"id":"W2171093150","doi":"10.1124/mol.109.061804","title":"Functional Characterization of Vasopressin Type 2 Receptor Substitutions (R137H/C/L) Leading to Nephrogenic Diabetes Insipidus and Nephrogenic Syndrome of Inappropriate Antidiuresis: Implications for Treatments","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute on Drug Abuse; National Institute of Mental Health; National Institutes of Health; Kidney Foundation of Canada","keywords":"Nephrogenic diabetes insipidus; Vasopressin; Endocrinology; Endocytosis; Internal medicine; Internalization; Vasopressin receptor; Arginine vasopressin receptor 2; Chemistry; Receptor; Biology; Medicine; Antagonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002850879,0.0003950565,0.0003473933,0.0003383345,0.0002158833,0.0002985658,0.0005211277,0.0006642878,0.002659968],"category_scores_gemma":[0.0005005429,0.0001456695,0.0005044439,0.0001858145,0.000566167,0.0002036247,0.0001793598,0.0006364557,0.0005642183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004407678,"about_ca_system_score_gemma":0.00039203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002042139,"about_ca_topic_score_gemma":0.001402166,"domain_scores_codex":[0.9997314,0.00005305199,0.00006098635,0.00004284906,0.00006506348,0.00004668242],"domain_scores_gemma":[0.9996524,0.0001114742,0.00007771731,0.00002587805,0.00003811399,0.00009443609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00056667,0.0001125569,0.001181784,0.00002951275,0.00002571157,0.001536967,0.00004326207,0.0002514399,0.9944829,0.0003828473,0.00008863369,0.001297636],"study_design_scores_gemma":[0.0004115897,0.001013644,0.02437913,0.00002371846,0.0001366896,0.01212711,0.0001681372,0.005086893,0.9534817,0.0002985898,0.002821969,0.00005082573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963451,0.0001591617,0.001547441,0.0001531864,0.00004632418,0.00005129551,0.0007629383,0.00002423493,0.0009102238],"genre_scores_gemma":[0.9969093,0.00009604642,0.001405396,0.0001532818,0.00001474265,0.00003369946,0.0007242356,0.00004832825,0.0006149791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002659968,"threshold_uncertainty_score":0.008898497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01173712280695287,"score_gpt":0.2610137286777995,"score_spread":0.2492766058708466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}