{"id":"W2171095905","doi":"10.1016/j.ymgme.2012.04.004","title":"Recommendations for the use of sapropterin in phenylketonuria","year":2012,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster Children's Hospital; Dalhousie University; Izaak Walton Killam Health Centre","funders":"Health Resources and Services Administration; University of Utah","keywords":"Phenylalanine hydroxylase; Medicine; Tetrahydrobiopterin; Neurocognitive; Dietary management; Metabolic control analysis; Dietary therapy; Hyperphenylalaninemia; Intensive care medicine; Pediatrics; Psychiatry; Phenylalanine; Internal medicine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581475,0.0001397794,0.0001655086,0.00005126604,0.00004979811,0.00002164749,0.0001335515,0.00008504391,0.00001125113],"category_scores_gemma":[0.00008384509,0.0001105908,0.00008183387,0.00009259552,0.00008606575,0.000005053844,0.0001007848,0.00004738482,6.907298e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.962563e-7,"about_ca_system_score_gemma":0.00002524716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003120653,"about_ca_topic_score_gemma":0.00001771635,"domain_scores_codex":[0.9991207,0.0000667128,0.0002512885,0.0001945046,0.00008814067,0.0002786214],"domain_scores_gemma":[0.9994031,0.00002833594,0.00007681768,0.0003558551,0.00005910504,0.00007676065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001118146,0.0002646623,0.007091932,0.00004862191,0.0001928549,3.843845e-7,0.0005239376,0.0006314951,0.8061947,0.00809637,0.003794328,0.1730489],"study_design_scores_gemma":[0.000722771,0.00002960023,0.03543167,0.00000505616,0.00008191523,0.00000288023,0.0000694605,0.0001845995,0.09872291,0.0002249506,0.8643614,0.0001627524],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9207568,0.04992649,0.02760517,0.0005225725,0.0004631917,0.0005616544,0.00006387301,0.000003464989,0.00009684439],"genre_scores_gemma":[0.9719853,0.006604963,0.02031209,0.0006035963,0.0001398671,0.0001032562,0.00006204765,0.00002846478,0.0001604505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8605671,"threshold_uncertainty_score":0.4509762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04172398556757321,"score_gpt":0.2793713827036254,"score_spread":0.2376473971360522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}