{"id":"W2171141151","doi":"10.1172/jci63735","title":"Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Kitasato University; Astellas Foundation for Research on Metabolic Disorders; Yasuda Memorial Medical Foundation; Cosmetology Research Foundation; Astellas Pharma; Ono Medical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation; Fukuoka Foundation for Sound Health; Sumitomo Foundation; Naito Foundation","keywords":"YAP1; Hippo signaling pathway; Biology; Embryonic stem cell; Cell biology; Progenitor cell; Keratinocyte; Cancer research; Mutant; Signal transduction; Stem cell; Cell culture; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002492717,0.001125839,0.0003957513,0.00212148,0.0004211302,0.0004110922,0.000436665,0.0009942013,0.005283596],"category_scores_gemma":[0.0001993741,0.0005510947,0.0004977178,0.0003525036,0.0005431941,0.000234823,0.000545142,0.001410373,0.001413959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003835767,"about_ca_system_score_gemma":0.0002871904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007646621,"about_ca_topic_score_gemma":0.001327221,"domain_scores_codex":[0.9996293,0.0000497282,0.00003743,0.0001354047,0.00009626504,0.00005190282],"domain_scores_gemma":[0.9995778,0.00004417084,0.0001534276,0.0000345659,0.00002186989,0.0001680869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002426518,0.00007816081,0.000545079,0.00003627723,0.00001359216,0.0005021389,0.00004011404,0.00007128801,0.9965053,0.0002690577,0.0001712776,0.001525129],"study_design_scores_gemma":[0.0003820226,0.001509611,0.04238497,0.0001115185,0.0001329008,0.01591351,0.0001828284,0.003392578,0.9196209,0.0005103786,0.01580176,0.00005705727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815439,0.001488041,0.00647789,0.0003875696,0.00009112551,0.0001552806,0.005246395,0.0007114587,0.003898282],"genre_scores_gemma":[0.9614767,0.002185463,0.007596268,0.0002299465,0.00004679244,0.0004054553,0.005032099,0.0004322955,0.02259499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005283596,"threshold_uncertainty_score":0.0176754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975450023300949,"score_gpt":0.3945181485009263,"score_spread":0.3047636482679168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}