{"id":"W2171141151","doi":"10.1172/jci63735","title":"Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Kitasato University; Astellas Foundation for Research on Metabolic Disorders; Yasuda Memorial Medical Foundation; Cosmetology Research Foundation; Astellas Pharma; Ono Medical Research Foundation; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation; Fukuoka Foundation for Sound Health; Sumitomo Foundation; Naito Foundation","keywords":"YAP1; Hippo signaling pathway; Biology; Embryonic stem cell; Cell biology; Progenitor cell; Keratinocyte; Cancer research; Mutant; Signal transduction; Stem cell; Cell culture; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003630198,0.0001027666,0.0002739113,0.0000372023,0.0000332959,0.00001593553,0.0001025984,0.0002329899,0.0000121111],"category_scores_gemma":[0.0006864116,0.00008498087,0.0001131648,0.00008180834,0.0001855291,0.00002080152,0.00003845485,0.0003422814,0.000002418062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002171054,"about_ca_system_score_gemma":0.000233307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006923879,"about_ca_topic_score_gemma":0.0001233438,"domain_scores_codex":[0.9983237,0.0003068488,0.00084975,0.0001655385,0.0001636634,0.0001904819],"domain_scores_gemma":[0.9988523,0.00009489725,0.0004877673,0.0001450002,0.0001556264,0.0002643803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002114006,0.0001158598,0.4500003,0.00002256811,0.00002776378,0.000001561033,0.0001074388,0.00005053563,0.5477043,0.00004082569,0.00008868258,0.00162874],"study_design_scores_gemma":[0.004281275,0.0007181571,0.5726212,0.0001782335,0.00009073834,0.00005603328,0.0001497552,0.0001888981,0.4139987,0.001195857,0.00620436,0.0003167898],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967417,0.001670716,0.0001100682,0.0008550846,0.0004681623,0.00008077477,0.000004777216,0.000002896813,0.00006588594],"genre_scores_gemma":[0.9974746,0.0004793167,0.0005419399,0.0004435204,0.0009828461,0.000002673484,0.000007105372,0.000008839239,0.00005921679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1337056,"threshold_uncertainty_score":0.3465419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975450023300949,"score_gpt":0.3945181485009263,"score_spread":0.3047636482679168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}